Sunitinib malate

Suppliers

Names

[ Name ]:
Sunitinib malate

[Synonym ]:
sunitinib L-malic acid salt
Sunitinib malate
sunitynib L-malate
L-malic acid salt of sunitinib
Sunitinib (Malate)

Chemical & Physical Properties

[ Density]:
1.3600 g/mL at 25 °C(lit.)

[ Boiling Point ]:
156 °C(lit.)

[ Melting Point ]:
189-191°C

[ Molecular Formula ]:
C₂₆H₃₃FN₄O₇

[ Molecular Weight ]:
532.561

[ Flash Point ]:
163 °F

[ Exact Mass ]:
532.233337

[ PSA ]:
172.06000

[ LogP ]:
2.77040

[ Index of Refraction ]:
n20/D 1.455(lit.)

[ Storage condition ]:
Store at +4°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360-H372

[ Precautionary Statements ]:
P201-P308 + P313

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-(-)-Malic acid
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
5-Fluoro-2-oxindole
L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
sunitinib
L-malic acid , ammonium-hydrogen-L malate
N1,N1-diethylethane-1,2-diamine (S)-2-hydroxysuccinate
5-fluoro-2-oxindole
sodium (4-((2-(diethylamino)ethyl)carbamoyl)-3,5-dimethyl-1H-pyrrol-2-yl)(hydroxy)methanesulfonate

DownStream

Articles

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST).

Oncotarget 6(4) , 1954-66, (2015)

c-Kit/α-PDGFR targeted therapies are effective for gastrointestinal stromal tumors (GIST), but, >50% develop drug resistance.RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imati...

Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro.

Biomaterials 78 , 115-28, (2015)

Formation of new lymphatic vessels, termed lymphangiogenesis, is central for diverse biological processes during development, inflammation and tumor metastasis. However, reliable in vitro model is sti...

Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells.

J. Pharmacol. Sci. 128 , 17-26, (2015)

Connexin (Cx) makes up a type of intercellular channel called gap junction (GJ). GJ plays a regulatory role in cellular physiology. The Cx expression level is often decreased in cancer cells compared ...

sunitinib maleate
4-Formyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
Sunitinib N-oxide
Sunitinib Amide Impurity
Sunitinib
Sunitinib-d4
N,N-diethyl-5-(5-{[4-(3-methylphenyl)piperazin-1-yl]methyl}-1,2,4-oxadiazol-3-yl)pyridin-2-amine
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
N-(2-(dimethylamino)-2-(thiophen-3-yl)ethyl)-4-phenyltetrahydro-2H-pyran-4-carboxamide
4-Amino-1-hexylpyridinium Bromide
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
(3,4-dimethoxyphenyl)-(2-phenyl-1H-imidazol-5-yl)methanone