Ethylhydrocupreine hydrochloride
Suppliers
Names
[ CAS No. ]:
3413-58-9
[ Name ]:
Ethylhydrocupreine hydrochloride
[Synonym ]:
numoquinhydrochloride
OPTICHIN HYDROCHLORIDE
Aethyl-hydrocuprein-hydrochlorid
MFCD00135594
EINECS 222-302-3
neumolisina
o-ethyl-hydrocupreinhydrochloride
hydrocupreine,ethylester,hydrochloride
OptochineHCl
optoquinhydrochloride
optochinhydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
508.7ºC at 760 mmHg
[ Melting Point ]:
121-123ºC
[ Molecular Formula ]:
C21H29ClN2O2
[ Molecular Weight ]:
376.92000
[ Flash Point ]:
261.5ºC
[ Exact Mass ]:
376.19200
[ PSA ]:
45.59000
[ LogP ]:
4.52720
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MW6300000
- CHEMICAL NAME :
- Hydrocupreine, O-ethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 3413-58-9
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C21-H28-N2-O2.Cl-H
- MOLECULAR WEIGHT :
- 376.97
- WISWESSER LINE NOTATION :
- T66 BNJ HO2 EYQ- DT66 A B CNTJ G2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 31 mg/kg/3D
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Vascular - regional or general arteriolar constriction
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 8,53,1916
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 8,53,1916
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 8,53,1916 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5575 No. of Facilities: 90 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 557 (estimated) No. of Female Employees: 502 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
S22;S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
MW6300000
[ HS Code ]:
29392900
Articles
Antimicrob. Agents Chemother. 51 , 3225-9, (2007)
The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selectio...
J. Med. Microbiol. 55(Pt 6) , 709-14, (2006)
It was previously reported that two oligonucleotide primer sets (spn9802 and spn9828) for discriminating Streptococcus pneumoniae from pneumococcus-like oral streptococcal isolates using PCR had been ...
Diagn. Microbiol. Infect. Dis. 42(4) , 263-8, (2002)
Standard identification of Streptococcus pneumoniae by optochin and bile solubility testing can lead to ambiguous results for certain isolates. Newer bacteriologic identification techniques (e.g., DNA...