MTIC

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Names

[ CAS No. ]:
3413-72-7

[ Name ]:
MTIC

[Synonym ]:
5-Monomethyltriazenoimidazole-4-carboxamide
5-(3-Monomethyl-1-triazeno)imidazole-4-carboxamide
(5E)-5-(methylaminohydrazinylidene)imidazole-4-carboxamide
5-(3-Methyl-1-triazeno)imidazole-4-carboxamide
1H-Imidazole-4-carboxamide,5-(3-methyl-1-triazenyl)
5-(3-methyltriazen-1-yl)imidazole-4-carboxamide
Imidazole-4-carboxamide,5-(3-methyl-1-triazeno)

Chemical & Physical Properties

[ Density]:
1.66g/cm3

[ Boiling Point ]:
306.7ºC at 760mmHg

[ Molecular Formula ]:
C5H8N6O

[ Molecular Weight ]:
168.15700

[ Flash Point ]:
139.3ºC

[ Exact Mass ]:
168.07600

[ PSA ]:
108.52000

[ LogP ]:
0.81790

[ Index of Refraction ]:
1.741

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI4000000
CHEMICAL NAME :
Imidazole-4-carboxamide, 5-(3-methyl-1-triazeno)-
CAS REGISTRY NUMBER :
3413-72-7
LAST UPDATED :
199712
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C5-H8-N6-O
MOLECULAR WEIGHT :
168.19
WISWESSER LINE NOTATION :
T5M CNJ DVZ ENUNM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4450 mg/kg/14W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rat Cells - not otherwise specified
DOSE/DURATION :
1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methylamine hydrochloride
  • 5-Diazoimidazole-4-carboxamide

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • MTIC-d3
  • TeMozoloMide Metabolite-MTIC
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine