[2-(aziridin-1-yl)piperidin-1-yl]-[4-[[4-(aziridin-1-yl)piperidin-1-yl]-oxophosphaniumyl]oxyphenoxy]-oxophosphanium

Names

[ CAS No. ]:
34180-21-7

[ Name ]:
[2-(aziridin-1-yl)piperidin-1-yl]-[4-[[4-(aziridin-1-yl)piperidin-1-yl]-oxophosphaniumyl]oxyphenoxy]-oxophosphanium

[Synonym ]:
a-205

Chemical & Physical Properties

[ Molecular Formula ]:
C20H30N4O4P2++

[ Molecular Weight ]:
452.42400

[ Exact Mass ]:
452.17400

[ PSA ]:
133.38000

[ LogP ]:
3.41820

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ4170000
CHEMICAL NAME :
Phosphinic acid, (1-aziridinyl)piperidino-, p-phenylene ester
CAS REGISTRY NUMBER :
34180-21-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H32-N4-O4-P2
MOLECULAR WEIGHT :
454.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 6,145,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
418 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 6,145,1971

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • tert-butyl N-{[1-(dimethylsulfamoyl)piperidin-4-yl]methyl}carbamate
  • 2-[4-({[(Benzyloxy)carbonyl](methyl)amino}methyl)phenoxy]acetic acid
  • Methyl 5-(1-{[(benzyloxy)carbonyl]amino}ethyl)-2-hydroxybenzoate
  • Ethyl 2-(3-{[(benzyloxy)carbonyl]amino}-2-hydroxyphenyl)acetate
  • 2-{[(Benzyloxy)carbonyl]amino}-2-methyl-3-phenoxypropanoic acid
  • benzyl N-(2-acetyl-4,5-dimethoxyphenyl)carbamate
  • Benzyl 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-3-hydroxypyrrolidine-1-carboxylate
  • 2-{benzyl[(prop-2-en-1-yloxy)carbonyl]amino}-2-(1-methyl-1H-pyrazol-5-yl)acetic acid
  • (2S)-3-(1-benzyl-1H-imidazol-4-yl)-2-{[(prop-2-en-1-yloxy)carbonyl]amino}propanoic acid
  • benzyl N-[3-cyano-5-(pyridin-4-yl)phenyl]carbamate
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