Clozapine N-oxide

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Names

[ CAS No. ]:
34233-69-7

[ Name ]:
Clozapine N-oxide

[Synonym ]:
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
Clozapine N-oxide
Clozapine (N-oxide)

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
517.4ºC at 760mmHg

[ Melting Point ]:
190-248ºC

[ Molecular Formula ]:
C18H19ClN4O

[ Molecular Weight ]:
342.823

[ Flash Point ]:
266.7ºC

[ Exact Mass ]:
342.124725

[ PSA ]:
57.06000

[ LogP ]:
0.76

[ Index of Refraction ]:
1.685

[ Storage condition ]:
2-8℃

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP1760000
CHEMICAL NAME :
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide
CAS REGISTRY NUMBER :
34233-69-7
LAST UPDATED :
198706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H19-Cl-N4-O
MOLECULAR WEIGHT :
342.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 43,309,1978

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
HP1760000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

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