EF24

Names

[ CAS No. ]:
342808-40-6

[ Name ]:
EF24

[Synonym ]:
EF-24
(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆ClF₂NO

[ Molecular Weight ]:
347.78600

[ Exact Mass ]:
347.08900

[ PSA ]:
29.10000

[ LogP ]:
4.73490

MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Oxopiperidinium chloride
2-Fluorobenzaldehyde
3,5-bis(2-fluorobenzylidene)-4-piperidone hydrochloride
acetic acid,3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one

DownStream

Articles

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.

Sci. Rep. 5 , 11836, (2015)

Cantharidin is an active constituent of mylabris, a traditional Chinese medicine, and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle co...

Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac.

Cell Cycle 15 , 381-93, (2016)

Previous studies have indicated that inflammatory stimulation represses protein phosphatase 2A (PP2A), a well-known tumor suppressor. However, whether PP2A repression participates in pancreatic cancer...

Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.

Crit. Care 17 , R199, (2014)

Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or s...

trans-N-Benzyl-3-hydroxy-2-pyrrolidi-none-4-carboxylic acid methyl ester
(1R,3R)-3-aminocyclohexane-1-carbonitrile
4-Amino-2,3-dimethylbutan-2-ol
2-[(1-Methyl-4-piperidyl)methoxy]pyridine-4-carbonitrile
2,5-Difluoro-3-hydroxyaniline
1-Amino-1-(3,4-difluorophenyl)acetone
1-Methoxy-2-[(1-methylethyl)sulfonyl]benzene
(R)-3-Tert-butoxycarbonylamino-3-cyclobutyl-propionic acid
2-(2,4-Dichlorophenyl)-1,3-benzoxazol-6-amine
2-(Chloromethyl)-1-(4-fluorophenyl)-1H-benzimidazole

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