EF24

Names

[ CAS No. ]:
342808-40-6

[ Name ]:
EF24

[Synonym ]:
EF-24
(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆ClF₂NO

[ Molecular Weight ]:
347.78600

[ Exact Mass ]:
347.08900

[ PSA ]:
29.10000

[ LogP ]:
4.73490

MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Oxopiperidinium chloride
2-Fluorobenzaldehyde
3,5-bis(2-fluorobenzylidene)-4-piperidone hydrochloride
acetic acid,3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one

DownStream

Articles

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.

Sci. Rep. 5 , 11836, (2015)

Cantharidin is an active constituent of mylabris, a traditional Chinese medicine, and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle co...

Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac.

Cell Cycle 15 , 381-93, (2016)

Previous studies have indicated that inflammatory stimulation represses protein phosphatase 2A (PP2A), a well-known tumor suppressor. However, whether PP2A repression participates in pancreatic cancer...

Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.

Crit. Care 17 , R199, (2014)

Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or s...

Isopropyl (R)-3-(4-amino-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzoate
(R)-1-(o-Tolyl)-4,5,6,7-tetrahydro-1H-indazol-4-amine
3-Hydroxyazetidine-1-carboximidamide
Ethyl 3-(4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzoate
(R)-1-(2-Fluoro-5-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-amine
8-Cyclopropyl-5,8-diazaspiro[3.5]nonane
1-(3-Chloropyrazin-2-yl)azetidin-3-ol
(4-(Thiophen-2-yl)pyrrolidin-3-yl)methanol
3-Bromo-5-ethynylpyridin-4-amine
(4-(5-Methylfuran-2-yl)pyrrolidin-3-yl)methanol

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