1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine

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Names

[ CAS No. ]:
343-90-8

[ Name ]:
1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine

[Synonym ]:
1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
1H-Indole-3-methanamine, 5-fluoro-N,N-dimethyl-
5-Fluorogramine
5-Fluor-gramin
3-dimethylaminomethyl-5-fluoroindole
MFCD00022731

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
297.7±25.0 °C at 760 mmHg

[ Melting Point ]:
145-149ºC

[ Molecular Formula ]:
C11H13FN2

[ Molecular Weight ]:
192.233

[ Flash Point ]:
133.8±23.2 °C

[ Exact Mass ]:
192.106277

[ PSA ]:
19.03000

[ LogP ]:
2.04

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7600000
CHEMICAL NAME :
Indole, 3-(dimethylamino)methyl-5-fluoro-
CAS REGISTRY NUMBER :
343-90-8
BEILSTEIN REFERENCE NO. :
0160256
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H13-F-N2
MOLECULAR WEIGHT :
192.26
WISWESSER LINE NOTATION :
T56 BMJ D1N1&1 GF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Fluoroindole
  • Eschenmoser's reagent
  • 5-Fluoroindole-2-carboxylic acid
  • Ethyl 5-fluoro-1H-indole-2-carboxylate
  • Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester
  • Formaldehyde
  • Dimethylamine

DownStream

  • (5-Fluoro-1H-indol-3-yl)acetic acid
  • 5-FLUOROINDOLE-3-ACETONITRILE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-(4-fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
  • 1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
  • 1-(1H-indol-3-yl)-N,N-dimethylmethanamine,hydrochloride
  • 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
  • 5-Bromogramine
  • 5-METHOXYGRAMINE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • N-(1-cyanocyclohexyl)-2-{[4-cyclopropyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propanamide
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide