1-Chloro-2,3,4,5,6-pentafluorobenzene

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Names

[ CAS No. ]:
344-07-0

[ Name ]:
1-Chloro-2,3,4,5,6-pentafluorobenzene

[Synonym ]:
EINECS 206-450-6
PENTAFLUOROCHLORO BENZENE
Chloropentafluorobenzene
chloropentafuorobenzene
MFCD00000534
Pentafluorophenyl chloride
Benzene, 1-chloro-2,3,4,5,6-pentafluoro-
Chloroperfluorobenzene
Benzene,chloropentafluoro
1-Chloro-2,3,4,5,6-pentafluorobenzene

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
123.8±35.0 °C at 760 mmHg

[ Melting Point ]:
18.1ºC

[ Molecular Formula ]:
C6ClF5

[ Molecular Weight ]:
202.509

[ Flash Point ]:
29.5±19.4 °C

[ Exact Mass ]:
201.960876

[ LogP ]:
2.28

[ Vapour Pressure ]:
15.8±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.422

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ1225500
CHEMICAL NAME :
Benzene, chloropentafluoro-
CAS REGISTRY NUMBER :
344-07-0
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C6-Cl-F5
MOLECULAR WEIGHT :
202.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4840 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/m3/6H/3W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/m3/6H/3W-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
62500 ug/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A187-233 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xn:Harmful;Xi:Irritant;

[ Risk Phrases ]:
R20

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
CZ1225500

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Pentafluorobenzene
  • PENTAFLUOROTHIOPHENOL
  • Pentafluorobenzenesulfenyl chloride
  • Bis(pentafluorophenyl) perdisulfide
  • lithium pentafluorobenzene
  • Hexachlorobenzene
  • 1,1-Dichloro-2,2-difluoroethene
  • α,α-dichlorodecafluoroisopropylbenzene
  • 2,3,4,5,6-Pentafluoroaniline
  • Perfluoropropylbenzene

DownStream

  • 1,2,4,5-Tetrafluorobenzene
  • tetrafluorobenzene
  • Pentafluorobenzene
  • 1,2,4-Trifluorobenzene
  • 2,3,5,6-Tetrafluorobenzonitrile
  • Benzonitrile,4,4'-[(2,4,5,6-tetrafluoro-m-phenylene)dioxy]bis[2,3,5,6-tetrafluoro- (8CI)
  • chlorotrifluoromethane
  • hexafluoroethane
  • Perfluorotoluene
  • IODOPENTAFLUOROBENZENE

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Gas chromatography with parallel hard and soft ionization mass spectrometry.

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Mass spectrometric identification of compounds in chromatography can be obtained from molecular masses from soft ionization mass spectrometry techniques such as field ionization (FI) and fragmentation...

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Resolution of the identity PBE (RI-PBE) and B3LYP density functional theory calculations are used to understand the cytochrome P450-catalyzed, Compound I-mediated oxidation of perchlorobenzenes, perfl...

Catalytic and Noncatalytic Ammonolysis of Chloropentafluorobenzene. Selivanova GA, et al.

Russ. J. Org. Chem. 37(3) , 404-9, (2001)


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Related Compounds

  • 1-Chloro-2,3,4,5,6-pentamethylbenzene
  • 1-chloro-2,3,4,5,6-pentakis(dichloromethyl)benzene
  • 1-Chloro-2,3,4,5,6-pentakis(trifluoromethyl)benzene
  • 1-(1-chloro-2,2-difluoroethenyl)-2,3,4,5,6-pentafluorobenzene
  • Chloro(2H5)benzene
  • 1-azidoselanyl-2,3,4,5,6-pentafluorobenzene
  • N-(3-Aminophenyl)octanamide
  • N,N-Dimethyl-N-[2-[(1-oxo-2-propen-1-yl)oxy]ethyl]-1-tetradecanaminium
  • 2-((5-(4-bromophenyl)-1-(p-tolyl)-1H-imidazol-2-yl)thio)-1-(piperidin-1-yl)ethanone
  • (6-chloroimidazo[1,2-a]pyridin-2-yl)methyl 4-acetyl-1H-pyrrole-2-carboxylate
  • N-(5-Amino-2-methylphenyl)octanamide
  • N-(pyridin-2-yl)-2-(1H-tetrazol-1-yl)benzamide
  • N~2~-[3-(1,3-benzothiazol-2-ylamino)-3-oxopropyl]-5,6-dimethoxy-1-methyl-1H-indole-2-carboxamide
  • 4-methyl-N-(4-pyridinylmethyl)-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide
  • N-{3-[(3-chloro-4-methoxyphenyl)amino]-3-oxopropyl}-4,6-dimethoxy-1-methyl-1H-indole-2-carboxamide
  • 3-(3-Nitropyridin-2-yl)oxybenzaldehyde
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