ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

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Names

[ CAS No. ]:
344-72-9

[ Name ]:
ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

[Synonym ]:
WLN: T5N CSJ BZ DMVO2 EXFFF
Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate
5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester
Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate
2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
ethyl 4-trifluoromethyl-2-aminothiazole-5-carboxylate
ethyl 2-amino-4-trifluoromethyl-5-thiazolecarboxylate
MFCD00153147
2-AMINO-4-(TRIFLUOROMETHYL)-5-(CARBETHOXY)THIAZOLE, MIN.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
329.7±42.0 °C at 760 mmHg

[ Melting Point ]:
170 °C

[ Molecular Formula ]:
C7H7F3N2O2S

[ Molecular Weight ]:
240.203

[ Flash Point ]:
153.2±27.9 °C

[ Exact Mass ]:
240.018036

[ PSA ]:
93.45000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.508

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ3675000
CHEMICAL NAME :
5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester
CAS REGISTRY NUMBER :
344-72-9
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H7-F3-N2-O2-S
MOLECULAR WEIGHT :
240.22
WISWESSER LINE NOTATION :
T5N CSJ BZ DMVO2 EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,142,1954

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2934100090

Synthetic Route

Precursor & DownStream

Precursor

  • Ethyl 2-chloro-4,4,4-trifluoroacetoacetate
  • Ethyl 2-bromo-4,4,4-trifluoro-3-oxobutanoate
  • Ethyl3-amino-4,4,4-trifluorocrotonate
  • 4-chlorodithiazol-5-one
  • Ethyl trifluoroacetoacetate

DownStream

  • 2-[(TERT-BUTOXYCARBONYL)AMINO]-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
  • ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
  • Ethyl 2-Bromo-4-(trifluoromethyl)thiazole-5-carboxylate
  • [2-[[4-(diethylamino)phenyl]diazenyl]-4-(trifluoromethyl)-1,3-thiazol-5-yl]methanol
  • ethyl 2-ethenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%


Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 3-Amino-1-(2,2,2-trifluoroethyl)piperidin-2-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-(8-Methoxy-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)butan-2-amine
  • 1-(4-Chlorophenyl)-3-cyclopropylpropane-1,3-dione
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 3-(4-Ethylphenyl)-2,2-dimethylpropan-1-amine