Betamipron

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Names

[ CAS No. ]:
3440-28-6

[ Name ]:
Betamipron

[Synonym ]:
3-Benzamidopropanoic acid
MFCD00037293
Benzoyl-β-alanine
3-benzamidopropionic acid
Betamipron
3-(Benzoylamino)propionic acid

Chemical & Physical Properties

[ Density]:
1.227 g/cm3

[ Boiling Point ]:
469.2ºC at 760 mmHg

[ Melting Point ]:
132 °C

[ Molecular Formula ]:
C10H11NO3

[ Molecular Weight ]:
193.19900

[ Flash Point ]:
237.6ºC

[ Exact Mass ]:
193.07400

[ PSA ]:
66.40000

[ LogP ]:
1.28200

[ Index of Refraction ]:
1.557

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY3272500
CHEMICAL NAME :
beta-Alanine, N-benzoyl-
CAS REGISTRY NUMBER :
3440-28-6
BEILSTEIN REFERENCE NO. :
2212769
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H11-N-O3
MOLECULAR WEIGHT :
193.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3496 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),140,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36 gm/kg/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),157,1991

Safety Information

[ WGK Germany ]:
3

[ RTECS ]:
AY3272500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzoyl chloride
  • beta-Alanine
  • (2S)-2-benzamidobutanedioic acid
  • 1-benzoylazetidin-2-one
  • N-(2-CHLOROETHYL)BENZAMIDE
  • N-(3-amino-3-oxopropyl)benzamide
  • Carbon dioxide
  • N-lithio-N-(2-lithioethyl)benzamide
  • tert-butyl 3-benzamidopropanoate
  • Benzaldoxime

DownStream

  • N-[2-(1H-BENZOIMIDAZOL-2-YL)-ETHYL]-BENZAMIDE
  • 3-Benzylamino-1-propanol
  • 1-benzoylimidazolidin-2-one
  • methyl 3-benzamidopropanoate
  • Benzamide,N,N'-1,4-butanediylbis-
  • N-(3-amino-3-oxopropyl)benzamide
  • N-benzyl-3-bromopropan-1-amine
  • benzoic acid

Articles

Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step.

Biochemistry 43(11) , 3230-7, (2004)

Beta-benzoyl-DL-alanine was synthesized from alpha-bromoacetophenone and diethyl acetamidomalonate. The racemic amino acid was resolved by carboxypeptidase A-catalyzed hydrolysis of the N-trifluoroace...

Thermodynamic quantitative structure-activity relationship analysis for enzyme-ligand interactions in aqueous phosphate buffer and organic solvent.

Bioorg. Med. Chem. 9(8) , 1951-5, (2001)

Thermodynamic quantitative structure-activity relationships (QSAR) for chymotrypsin-ligand binding is developed, and the results are compared for the effects of organic solvent on the substrate specif...

Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits.

Biopharm. Drug Dispos. 20(3) , 125-9, (1999)

The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA-1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without b...


More Articles

Related Compounds

  • panipenem-betamipron
  • Tert-butyl 6-[(but-2-ynamido)methyl]-5-oxa-2-azaspiro[3.5]nonane-2-carboxylate
  • 2-Chloro-N-[2-hydroxy-3-(1-oxoisoquinolin-2-yl)propyl]acetamide
  • 2-Chloro-N-[2-(2-chloro-5-hydroxyphenyl)-2-hydroxyethyl]-N-methylacetamide
  • N-[6-Fluoro-7-(trifluoromethyl)-3,4-dihydro-2H-chromen-3-yl]but-2-ynamide
  • N-[[4-Methoxy-3-(morpholin-4-ylmethyl)phenyl]methyl]but-2-ynamide
  • N-(2-{4-[methyl(propan-2-yl)amino]piperidin-1-yl}ethyl)but-2-ynamide
  • (2E)-4-(dimethylamino)-N-[4-(1H-pyrazol-4-yl)butyl]but-2-enamide
  • N-(1-Morpholin-4-yl-1-phenylpropan-2-yl)but-2-ynamide
  • (2E)-4-(dimethylamino)-N-methyl-N-(1,1,1-trifluoro-4-phenylbutan-2-yl)but-2-enamide
  • N-[cyano(3-hydroxyphenyl)methyl]-N-methylbut-2-ynamide
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