1-(2-Hydroxyethyl)-2-pyrrolidinone

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Names

[ CAS No. ]:
3445-11-2

[ Name ]:
1-(2-Hydroxyethyl)-2-pyrrolidinone

[Synonym ]:
N-(2-Hydroxyethyl)-2-pyrrolidone
1-(2-Hydroxyethyl)-2-Pyrrolidone
1-(2-hydroxyethyl)pyrrolidin-2-one
N-(2-hydroxyethyl)-2-oxo-pyrrolidine
EINECS 222-359-4
N-(2-hydroxyethyl)-pyrrolidinone
N-2-Hydroxyethylpyrrolidin-2-one
N-(2-hydroxyethyl)-2-pyrrolidinone
1-(2-Hydroxyethyl)-2-pyrrolidinone
2-Pyrrolidinone,1-(2-hydroxyethyl)
2-Pyrrolidinone, 1-(2-hydroxyethyl)-
MFCD00014103

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
296.0±13.0 °C at 760 mmHg

[ Melting Point ]:
19-21°C

[ Molecular Formula ]:
C6H11NO2

[ Molecular Weight ]:
129.157

[ Flash Point ]:
132.8±19.8 °C

[ Exact Mass ]:
129.078979

[ PSA ]:
40.54000

[ LogP ]:
-1.02

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.505

[ Stability ]:
Stable. Incompatible with strong oxidizing agents

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY5776500
CHEMICAL NAME :
2-Pyrrolidinone, 1-(2-hydroxyethyl)-
CAS REGISTRY NUMBER :
3445-11-2
BEILSTEIN REFERENCE NO. :
0112181
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H11-N-O2
MOLECULAR WEIGHT :
129.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0682-0448S ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0682-0448S

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
UY5776500

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Oxo-1-Pyrrolidineacetic Acid Methyl Ester
  • gamma-Butyrolactone
  • 2-Aminoethanol
  • Methyl 4-oxobutanoate
  • Etoxybamide
  • 1-(2-chloroethyl)pyrrolidin-2-one
  • ETHYLENE OXIDE
  • Pyrrolidine
  • 2-Pyrrolidinone

DownStream

  • 1-(2-chloroethyl)pyrrolidin-2-one
  • 2-Pyrrolidinone
  • N-Ethyl-2-pyrrolidone
  • 3-Vinyl-2-pyrrolidinone
  • ch3cho
  • Piracetam
  • 1-(2-Bromoethyl)pyrrolidin-2-one
  • 3-(2-oxopyrrolidin-1-yl)propanenitrile
  • (2-Oxo-1-pyrrolidinyl)acetaldehyde
  • 2-Pyrrolidinone,1-[2-(ethenyloxy)ethyl]-

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Related Compounds

  • 1-[2-hydroxyethyl-[2-(2-hydroxyethyl-(2-hydroxypropyl)amino)ethyl]amino]propan-2-ol
  • 1-(2-hydroxyethyl)-2-benzoylbenzimidazole
  • 1-(2-hydroxyethyl)-2-methyl-5-aminoimidazole
  • 1-(2-hydroxyethyl)-2-cyclohexen-1-ol
  • 1-(2-Hydroxyethyl)-2-methyl-3-phenylpyrrolidin-3-ol 3-propionate
  • 1-(2-hydroxyethyl)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol