Ketotifen

Suppliers

Names

[ CAS No. ]:
34580-13-7

[ Name ]:
Ketotifen

[Synonym ]:
Ketotifeno
Ketotiphene
Ketotifene
Ketotiphen
Ketotifenum
ketotifen
Zaditen

Chemical & Physical Properties

[ Density]:
1.236g/cm3

[ Boiling Point ]:
488.9ºC at 760mmHg

[ Melting Point ]:
152-153ºC

[ Molecular Formula ]:
C19H19NOS

[ Molecular Weight ]:
309.42500

[ Flash Point ]:
249.5ºC

[ Exact Mass ]:
309.11900

[ PSA ]:
48.55000

[ LogP ]:
3.95230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE8255000
CHEMICAL NAME :
10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
CAS REGISTRY NUMBER :
34580-13-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H19-N-O-S
MOLECULAR WEIGHT :
309.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
179 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,13,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,13,1987

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4H-Benzo[4,5]cyclohepta[1,2-b]thiophene-4-ol,10-methoxy-4-(1-methyl-4-piperidinyl)-
  • 10-hydroxy-10-(1-methylpiperidin-4-yl)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
  • 10-Methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one
  • 4-Chloro-1-methylpiperidine
  • 4-(10-bromo-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methyl-piperidine
  • 4H-Benzo[4,5]cyclohepta[1,2-b]thiophen-4-one,9,10-dihydro-
  • 9,10-DIBROMO-9,10-DIHYDRO-4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE-4-ONE
  • magnesium,1-methylpiperidin-4-ide,chloride
  • 10-bromo-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-4-one

DownStream

  • 10-(1-methyl-1-oxidopiperidin-1-ium-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
  • 10-(1-methylpiperidin-4-ylidene)-4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-4-ol
  • Ketotifen Impurity G