polythiazide (200 mg)

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Names

[ CAS No. ]:
346-18-9

[ Name ]:
polythiazide (200 mg)

[Synonym ]:
Polythiazide
Polythiazidum
Politiazida
Nephril
P-2525
Renese
Drenusil

Chemical & Physical Properties

[ Density]:
1.598g/cm3

[ Boiling Point ]:
580.1ºC at 760mmHg

[ Melting Point ]:
202.5°

[ Molecular Formula ]:
C₁₁H₁₃ClF₃N₃O₄S₃

[ Molecular Weight ]:
439.88200

[ Flash Point ]:
304.7ºC

[ Exact Mass ]:
438.97100

[ PSA ]:
151.63000

[ LogP ]:
4.59280

[ Index of Refraction ]:
1.566

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK9275000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl- 3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 346-18-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H13-Cl-F3-N3-O4-S3

MOLECULAR WEIGHT :: 439.90

WISWESSER LINE NOTATION :: T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 ug/kg/5D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

Related Compounds

CEPHRADINE (200 MG)
haloprogin (200 mg)
Sucromalt (200 mg)
GADOVERSETAMIDE (200 MG)
ipodate sodium (200 mg)
iocetamic acid (200 mg)
1,2,4-Triazolo[4,3-a]pyrimidin-7(1H)-one, 5-amino-3-(ethylthio)-
2-[(4-Bromophenyl)imino]-5-(2-thienylmethylene)-1,3-thiazolidin-4-one
2-[(4-Bromophenyl)imino]-5-(2,5-dimethoxybenzylidene)-1,3-thiazolidin-4-one
5-[4-(Allyloxy)benzylidene]-2-[(4-chlorophenyl)imino]-1,3-thiazolidin-4-one
tert-butyl 4-{4-bromo-1H-pyrrolo[2,3-b]pyridin-2-yl}piperidine-1-carboxylate
5-[4-(Methylsulfanyl)piperidin-1-yl]furan-2-carbaldehyde
1H-Indole-3-carboximidamide hydrochloride
(3-Formylphenyl)(methoxy)methaniminium chloride
4-Chloro-2-((2,2-dimethylthietan-3-yl)amino)thiazole-5-carbonitrile
3-((2,2-Dimethylthietan-3-yl)amino)-2,3-dioxopropanoicacid

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