3-methylflavone-8-carboxylic acid

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Names

[ Name ]:
3-methylflavone-8-carboxylic acid

[Synonym ]:
8-carboxy-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran
3-Methylflavone-8-ca
3-Methylflavone-8-carboxylicacid
3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid
3-methyl-4-oxo-2-phenyl
3-Methylflavone-8-carboxylic
3-Methylflavone-8-carboxylic Acid
EINECS 222-425-2
8-CARBOXY-3-METHYLFLAVONE
8-carboxyl-3-methylflavone
3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid
Flavoxate impurity A
4H-1-Benzopyran-8-carboxylic acid
MFCD00040998
4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl-
3-Methyl-2-phenylchromone-8-carboxylic Acid
4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-
3-methyl-4-oxo-2-phenylchromene-8-carboxylic acid
2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
485.1±45.0 °C at 760 mmHg

[ Melting Point ]:
234-236°C

[ Molecular Formula ]:
C₁₇H₁₂O₄

[ Molecular Weight ]:
280.28

[ Flash Point ]:
183.3±22.2 °C

[ Exact Mass ]:
280.073547

[ PSA ]:
67.51000

[ LogP ]:
3.47

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.643

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

8-formyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran
8-(1,2-epoxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Pharmacological activities of the main metabolite of flavoxate 3-methylflavone-8-carboxylic acid.

Arzneimittelforschung 38(3) , 379-82, (1988)

The pharmacological properties of 3-methylflavone-8-carboxylic acid (MFCA), the main metabolite of flavoxate, have been studied in vitro and in vivo. MFCA did not display antispasmodic activity on iso...

Determination of 3-methylflavone-8-carboxylic acid, the main metabolite of flavoxate, in human urine by capillary electrophoresis with direct injection.

J. Chromatogr. A. 612(2) , 287-94, (1993)

The effects of tetraalkylammonium salts and sodium dodecyl sulphate on the migration behaviour of human urinary components and other negatively charged or neutral solutes were investigated. The sulpha...

Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder.

Urology 37(4) , 390-4, (1991)

The antispasmodic effects of the flavone compounds flavoxate hydrochloride, 3-methylflavone carboxylic acid (MFCA), and REC 15/2053 (and in the case of the detrusor, oxybutynin), on the human detrusor...

3-Methylflavone-8-carboxylic Acid-d5
3-methylflavone-8-carboxylic acid chloride
2'-ethyl-3-methylflavone-8-carboxylic acid
4'-ethyl-3-methylflavone-8-carboxylic acid
2'-ethoxy-3-methylflavone-8-carboxylic acid
2'-chloro-3-methylflavone-8-carboxylic acid
1-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetyl}-2-methylpiperidine-2-carboxylic acid
methyl 5-[1-(aminomethyl)cyclobutyl]-1-methyl-1H-pyrazole-3-carboxylate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
2,2-Difluoro-1-[4-(trifluoromethyl)phenyl]cyclopropane-1-carboxylic acid
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde