p-Fluoro-β-chloropropiophenone

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Names

[ CAS No. ]:
347-93-3

[ Name ]:
p-Fluoro-β-chloropropiophenone

[Synonym ]:
p-Fluoro-β-chloropropiophenone
EINECS 206-475-2
3-chloro-1-(4-fluorophenyl)propan-1-one
β-Chloro-para-fluoropropiophenone
p-fluoro-|A-chloropropiophenone
3-Chlor-1-(4-fluorphenyl)propan-1-on
1-Propanone, 3-chloro-1-(4-fluorophenyl)-
3-Chloro-1-(4-fluorophenyl)-1-propanone
3-Chloro-4-Fluoropropiophenone
3-CHLORO-4'-FLUOROPROPIOPHENONE
MFCD00000991

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
277.3±20.0 °C at 760 mmHg

[ Melting Point ]:
47-49 °C(lit.)

[ Molecular Formula ]:
C₉H₈ClFO

[ Molecular Weight ]:
186.611

[ Flash Point ]:
92.2±0.0 °C

[ Exact Mass ]:
186.024765

[ PSA ]:
17.07000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.510

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ Hazard Class ]:
4.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

1-(4-fluorophenyl)-3-phenylpropan-1-one
Paroxetine
5-Fluoro-2,3-dihydro-1H-inden-1-one
6-Fluorindan-1-on
(3S)-3-Z-AMINO-1-DIAZO-2-BUTANONE
((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
1-(4-fluorophenyl)prop-2-en-1-one
2,3-DIHYDRO-5-FLUORO-1H-INDEN-1-OL

Articles

Synthesis and pharmacological evaluation of novel arylpiperazine derivatives as nonsteroidal androgen receptor antagonists.

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The search for novel antiandrogens by high-throughput screening (HTS) of the Yamanouchi chemical library led to the discovery of the lead compound (5), which possesses an arylmorpholine moiety. Throug...

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