1-Bromo-2,4-difluorobenzene

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Names

[ CAS No. ]:
348-57-2

[ Name ]:
1-Bromo-2,4-difluorobenzene

[Synonym ]:
2,4-Difluorophenyl bromide
2,4-Difluorobromobenzene
Bromo-2,4-difluorobenzene
1-Bromo-2,4-difluoro
1-bromo-2,4-difluoro-benzene
2,4-diFC6H3Br
Benzene,1-bromo-2,4-difluoro
EINECS 206-479-4
Benzene, 1-bromo-2,4-difluoro-
2,4-Difluoro-1-bromobenzene
1-Bromo-2,4-difluorobenzene
4-Bromo-1,3-difluorobenzene
FR CF DE
2,4-Difluoro
MFCD00000330

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
148.4±20.0 °C at 760 mmHg

[ Melting Point ]:
−4 °C(lit.)

[ Molecular Formula ]:
C6H3BrF2

[ Molecular Weight ]:
192.989

[ Flash Point ]:
51.7±0.0 °C

[ Exact Mass ]:
191.938614

[ LogP ]:
2.98

[ Vapour Pressure ]:
5.4±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.507

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36/37/39-S37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-Difluorobenzene
  • 2-Bromo-1,3-difluorobenzene
  • (2,4-Difluorophenyl)trimethylsilane
  • Acetonitrile
  • benzene

DownStream

  • 1,3-Difluorobenzene
  • Bromoacetonitrile
  • 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
  • 2-(2,4-Difluorophenyl)pyridine
  • 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE
  • 2,4-Difluorobiphenyl
  • (2,4-Difluorophenyl)trimethylsilane
  • (R)-2-(2,4-difluoro-phenyl)-3-[1H-1,2,4]triazoll-1-yl-propane-1,2-diol
  • [2-(2,4-difluorophenyl)oxiran-2-yl]methanol
  • 4-Bromo-3-fluoroanisole

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Optically active antifungal azoles: synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol.

Bioorg. Med. Chem. 12(9) , 2225-38, (2004)

A series of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol (11a-n) and (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-...

Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes. Mongin F and Schlosser M.

Tetrahedron Lett. 37(36) , 6551-54, (1996)

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents. Yasohara Y, et al.

Tetrahedron Lett. 42(19) , 3331-3, (2001)


More Articles

Related Compounds

  • 1-Bromo-2,4-difluorobenzene
  • 1-bromo-2,4-dichloro-3,5-difluorobenzene
  • 1-Bromo-2,4-difluoro-5-ethoxybenzene
  • 1-Bromo-2-chloro-3,4-difluorobenzene
  • 1-Bromo-2-ethoxy-3,4-difluorobenzene
  • 1-bromo-2-(1-ethoxyethoxymethyl)-3,4-difluorobenzene
  • 3-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-3-methylbutanoic acid
  • (3S)-3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-fluorophenyl]formamido}butanoic acid
  • (3R)-3-({1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)pentanoic acid
  • 8-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]octanoic acid
  • (3S)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-phenylacetamido]pentanoic acid
  • (3R)-3-{[4-bromo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}pentanoic acid
  • (3S)-3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-phenylpropanamido]butanoic acid
  • 3-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]butanoic acid
  • 6-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]hexanoic acid
  • 4-{2-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]ethyl}-5-methylhexanoic acid
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