1-(2-Pyridinyl)piperazine

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Names

[ CAS No. ]:
34803-66-2

[ Name ]:
1-(2-Pyridinyl)piperazine

[Synonym ]:
2-(1-Piperazinyl)pyridine
1-(pyridin-2-yl)piperazine
2-Piperazinopyridine
1-(2-Pyridinyl)piperazine
Piperazine, 1-(2-pyridinyl)-
MFCD00006216
EINECS 252-220-3
2-pyridylpiperazine
1-(2-Pyridyl)Piperazine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
314.4±22.0 °C at 760 mmHg

[ Melting Point ]:
92-94

[ Molecular Formula ]:
C9H13N3

[ Molecular Weight ]:
163.22

[ Flash Point ]:
143.9±22.3 °C

[ Exact Mass ]:
163.110947

[ PSA ]:
28.16000

[ LogP ]:
0.19

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
Flammables area

[ Water Solubility ]:
>500 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2735

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperazine
  • 2-Bromopyridine
  • 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
  • 2-Chloropyridine
  • ethyl-4-(2-pyridyl)-1-piperazine carboxylate

DownStream

  • 1-but-3-ynyl-4-pyridin-2-ylpiperazine
  • Piperazine, 1-methyl-4-(2-pyridinyl)- (9CI)
  • CHEMBRDG-BB 4012280
  • 4-PYRIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE
  • 1-(6-chloropyridin-2-yl)piperazine
  • N-(4-propan-2-ylsulfanylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propanamide
  • 2-(4-pyridin-2-ylpiperazin-1-yl)propanoic acid
  • 1-(2-Phenylethyl)-4-(2-pyridinyl)piperazine
  • 1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, hydrazide
  • N-Methylaniline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacological evidence for the involvement of 1-(2-pyridinyl)-piperazine (1-PmP) in the interaction of buspirone or gepirone with noradrenergic systems.

Eur. J. Pharmacol. 134(1) , 113-6, (1987)

We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 ...

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

Drug Metab. Dispos. 35(8) , 1387-92, (2007)

The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distributi...

New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.

Bioorg. Med. Chem. 16 , 8737-44, (2008)

Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinoma (HCT-11...


More Articles

Related Compounds

  • 3-methyl-1-(2-pyridinyl)piperazine
  • 1-(2-pyridinyl)piperazine hydrochloride
  • 1-(2-Pyridinyl)piperazine dihydrochloride
  • (3R,5S)-3,5-Dimethyl-1-(2-pyridinyl)piperazine
  • 1-(2-Pyridinyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl) piperazine
  • 1-(2-Chloro-4-pyridinyl)piperazine
  • Tert-butyl 4-(dimethylamino)-4-propylazepane-1-carboxylate
  • Tert-butyl 4-(azetidin-1-yl)-4-propylazepane-1-carboxylate
  • Tert-butyl 4-propyl-4-(thiomorpholin-4-yl)azepane-1-carboxylate
  • 1-{3-Amino-6-azabicyclo[3.2.1]octan-6-yl}but-3-yn-1-one
  • tert-Butyl (2-acetyl-5-methoxyphenyl)carbamate
  • 1-[4-(Diethylamino)phenyl]cyclopropane-1-carbonitrile
  • 2-(8-Methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)azetidine
  • Methyl 4-amino-4-(2-cyanophenyl)butanoate
  • 1-{3-Amino-6-azabicyclo[3.2.1]octan-6-yl}pent-4-yn-1-one
  • 4-{3-Amino-6-azabicyclo[3.2.1]octan-6-yl}-4-oxobutanoic acid
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