3-(4-methylphenyl)-1,2,35-oxadiazol-5-ol

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Names

[ CAS No. ]:
3483-19-0

[ Name ]:
3-(4-methylphenyl)-1,2,35-oxadiazol-5-ol

[Synonym ]:
Sydnone,3-p-tolyl
3-p-tolyl-sydnone
N-tolyl-sydnone

Chemical & Physical Properties

[ Molecular Formula ]:
C9H8N2O2

[ Molecular Weight ]:
176.17200

[ Exact Mass ]:
176.05900

[ PSA ]:
52.97000

[ LogP ]:
1.40350

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WU7694500
CHEMICAL NAME :
Sydrone, 3-p-tolyl-
CAS REGISTRY NUMBER :
3483-19-0
BEILSTEIN REFERENCE NO. :
3672154
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H8-N2-O2
MOLECULAR WEIGHT :
176.19
WISWESSER LINE NOTATION :
T5NNOVJ AR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
753 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 14,369,1965

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-[(4-methylphenyl)-nitroso-amino]acetic acid
  • Glycine,N-(4-methylphenyl)-
  • Ethyl [(4-methylphenyl)amino]acetate
  • p-Toluidine

DownStream

  • 4-Methylphenylhydrazine hydrochloride
  • 2-(4-methylphenyl)indazole

Related Compounds

  • 3-(4-METHYLPHENYL)-1,2,4-OXADIAZOL-5-YL]ACETONITRILE
  • 4-[3-(4-METHYLPHENYL)-1,2,4-OXADIAZOL-5-YL]PYRIDINE
  • 1-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]ethanamine
  • 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]ethanamine
  • 3-{[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-2,4(1H,3H)-quinazolinedione
  • 4-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]aniline