Metiamide

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Names

[ Name ]:
Metiamide

[Synonym ]:
metiamide
Thiourea, N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-
Metiamidum
Metiamida
SK&Methiamide
Thiourea, N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-
1-Methyl-3-(2-{[(4-methyl-1H-imidazol-5-yl)methyl]sulfanyl}ethyl)thiourea

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
463.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₆N₄S₂

[ Molecular Weight ]:
244.380

[ Flash Point ]:
233.8±31.5 °C

[ Exact Mass ]:
244.081635

[ PSA ]:
110.13000

[ LogP ]:
0.65

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT7750000

CHEMICAL NAME :: Urea, 1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)et hyl)-2-thio-

CAS REGISTRY NUMBER :: 34839-70-8

LAST UPDATED :: 198703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H16-N4-S2

MOLECULAR WEIGHT :: 244.41

WISWESSER LINE NOTATION :: T5M CNJ D1S2MYUS&M1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1493 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2642 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 umol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

Safety Information

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethylamine dihydrochloride
Methyl isothiocyanate
4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

4-Formyl-1-methyl-1H-pyrazole-5-carbonitrile
methyl (2Z)-3-cyclobutyl-3-cyclopropylprop-2-enoate
(2R)-2-({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolan-2-yl}formamido)-4-methylpentanoic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1,3-thiazol-5-yl)propanamido]-2,2-dimethylpropanoic acid
1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxy-2-methylpropanoyl]-4,4-dimethylpyrrolidine-3-carboxylic acid
2-[(1RS,3SR)-3-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methylsulfanyl)butanamido]cyclopentyl]acetic acid
(3R)-1-{2-[(1RS,3SR)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetyl}piperidine-3-carboxylic acid
ethyl (2Z)-3-(3,4-dimethylphenyl)but-2-enoate
tert-butyl N-(4-fluoro-2-nitrophenyl)-N-(propan-2-yl)carbamate
2,6-dibromo-N-ethyl-4-methylbenzene-1-sulfonamide

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