3-CYANOQUINOLINE

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Names

[ CAS No. ]:
34846-64-5

[ Name ]:
3-CYANOQUINOLINE

[Synonym ]:
Chinolin-3-carbonsauerenitril
EINECS 252-248-6
3-quinolinenitrile
3-cyano-quinoline
MFCD00006766
3-Quinolinecarbonitrile
3-cyanoisoquinoline
3-CYANOQUINOLINE
quinoline-3-carbonitrile

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
323.7±15.0 °C at 760 mmHg

[ Melting Point ]:
108-110 °C(lit.)

[ Molecular Formula ]:
C10H6N2

[ Molecular Weight ]:
154.168

[ Flash Point ]:
115.5±5.6 °C

[ Exact Mass ]:
154.053101

[ PSA ]:
36.68000

[ LogP ]:
1.57

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.654

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Bromoquinoline
  • Sodium cyanide
  • POTASSIUM CYANIDE
  • 2-[acetyloxymethyl(2-nitrophenyl)]acrylonitrile
  • zinc,dicyanide
  • 3-Iodoquinoline
  • Copper cyanide
  • 3-Methylquinoline
  • 2-Nitrobenzaldehyde

DownStream

  • 2-chloro-3-cyanoquinoline
  • leucoline
  • quinoline-3-carboximidamide
  • Quinoline-3-carboxylic acid
  • methyl quinoline-3-carboxylate
  • 3-Quinolinecarboxaldehyde
  • quinoline-3-carboxamide
  • 1-methyl-4H-quinoline-3-carbonitrile
  • 1-benzyl-2H-quinoline-3-carbonitrile
  • 1-[[4-(trifluoromethyl)phenyl]methyl]quinolin-1-ium-3-carbonitrile,bromide

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey.

Anal. Bioanal. Chem 407 , 6159-70, (2015)

Time-of-flight accurate mass spectrometry (TOF-MS), following a previous chromatographic (gas or liquid chromatography) separation step, is applied to the identification and structural elucidation of ...

Exploitation of the 3-quinolinecarbonitrile template for SRC tyrosine kinase inhibitors.

Curr. Top. Med. Chem 8(10) , 922-34, (2008)

In 2000, Wyeth reported that the 3-quinolinecarbonitrile ring system was a template for EGFR inhibitors. It soon became apparent that the group at C-4 of this core was responsible for kinase selectivi...


More Articles

Related Compounds

  • 3-cyanoquinoline N-oxide
  • 4-chlro-3-cyanoquinoline
  • 2-bromo-3-cyanoquinoline
  • 2-chloro-3-cyanoquinoline
  • 2-Methyl-3-cyanoquinoline
  • 3-Cyanoquinoline-2,4-dione
  • Dimethyl[1-(piperidin-3-YL)propyl]amine
  • 2-(2-Bromo-4,5-difluorophenyl)propanoic acid
  • 2-(2,5-Dimethoxyphenyl)butan-1-amine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N,2,4-trimethyl-5-nitroaniline