3-Acetylpyridine

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Names

[ CAS No. ]:
350-03-8

[ Name ]:
3-Acetylpyridine

[Synonym ]:
3-PYRIDYL METHYL KETONE
Methyl pyridin-3-yl ketone
1-(3-Pyridinyl)ethanone
1-(Pyridin-3-yl)ethanon
3-Acetylpyridine
Methyl pyridyl ketone
1-(pyridin-3-yl)ethanone
3-Acetopyridine
β-Acetylpyridine
3-acetyl-pyridine
EINECS 206-496-7
MFCD00006396
methyl 3-pyridyl ketone
Ketone,methyl 3-pyridyl
Ethanone, 1-(3-pyridinyl)-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
220.8±13.0 °C at 760 mmHg

[ Melting Point ]:
11-13 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO

[ Molecular Weight ]:
121.137

[ Flash Point ]:
150.0±0.0 °C

[ Exact Mass ]:
121.052765

[ PSA ]:
29.96000

[ LogP ]:
0.47

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Water Solubility ]:
SOLUBLE IN HOT WATER

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB5425000

CHEMICAL NAME :: Ketone, methyl 3-pyridyl

CAS REGISTRY NUMBER :: 350-03-8

BEILSTEIN REFERENCE NO. :: 0107751

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: T6NJ CV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46 uL/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Musculoskeletal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 422 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 5000 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,23,1986 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/38

[ Safety Phrases ]:
S45-S37/39-S28A-S26

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
OB5425000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Precursor & DownStream

Precursor

3-(1-Hydroxyethyl)pyridine
3-Bromopyridine
Acetyl chloride
N-Butyl Vinyl Ether
Ethene,1,1'-[1,2-ethanediylbis(oxy)]bis-
3-Chloropyridine
Ethoxyethene
bis-(1-pyridin-3-yl-ethylidene)-hydrazine
3-Acetylpyridine N-Oxide
3-Oxo-3-(3-pyridinyl)propanenitrile

DownStream

1-Trimethylsilyloxy-1-(3-pyridyl)-ethene
2-PYRIDIN-3-YL PIPERAZINE
2,2-Diethoxy-2-pyridin-3-yl-ethylamine dihydrochloride
Ethanone, 1-(3-pyridinyl)-, oxime, (1E)- (9CI)
2,2,2-Trifluoro-1-(3-pyridinyl)ethanone
3-(1H-pyrrol-2-yl)pyridine
1-(3-Pyridinyl)-1-ethanone oxime
1-(3-Pyridinyl)ethanamine
6-BROMO-2-PYRIDIN-3-YL-QUINOLINE-4-CARBOXYLICACID

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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Anal. Biochem. 434(1) , 187-98, (2013)

In the current study, we compared plastic matrix-assisted laser desorption/ionization (MALDI) plates pre-spotted with different solid ionic matrices. Data reflect that after 3 months of storage, the s...

Cyanoacetic acid hydrazones of 3-(and 4-)acetylpyridine and some derived ring systems as potential antitumor and anti-HCV agents.

Arch. Pharm. (Weinheim) 339(1) , 14-23, (2006)

Two new acetylpyridinehydrazones derived from cyanoacetic acid hydrazide have been synthesized namely: cyanoacetic acid (1-pyridin-3 or 4-yl-ethylidene) hydrazides (1a,b). and some derived ring system...

Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold.

J. Biomed. Mater. Res. A 102(11) , 4027-36, (2014)

Human-induced pluripotent stem cells (hiPSCs) are considered to be potentially able to differentiate into all human cell lineages and thus hold promise as an unlimited source for cell replacement ther...