Prajmaline

Suppliers

Names

[ CAS No. ]:
35080-11-6

[ Name ]:
Prajmaline

[Synonym ]:
N-n-Propyl-21-epi-isoajmalinium Kation
Prajmalium
N-Propylajmaline
N-Propyl-ajmalinium

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₃N₂O₂+

[ Molecular Weight ]:
369.52000

[ Exact Mass ]:
369.25400

[ PSA ]:
43.70000

[ LogP ]:
2.50310

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AX8155800

CHEMICAL NAME :: Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21-alpha)-

CAS REGISTRY NUMBER :: 35080-11-6

LAST UPDATED :: 198602

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H33-N2-O2

MOLECULAR WEIGHT :: 369.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 ug/kg

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,36,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65500 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,2329,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,2329,1974