3-(trifluoromethyl)acetanilide

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Names

[ CAS No. ]:
351-36-0

[ Name ]:
3-(trifluoromethyl)acetanilide

[Synonym ]:
m-Trifluoromethyl acetanilide
N-acetyl-3-trifluoromethylbenzenamine
3-CF3C6H4NHAc
USAF MA-14
3-Trifluoromethylacetanilide
3-Acetamidobenzotrifluoride
m-Acetaminobenzotrifluoride
EINECS 206-512-2
MFCD00000383

Chemical & Physical Properties

[ Density]:
1.302g/cm3

[ Boiling Point ]:
292ºC at 760mmHg

[ Melting Point ]:
103-106ºC

[ Molecular Formula ]:
C9H8F3NO

[ Molecular Weight ]:
203.16100

[ Flash Point ]:
130.4ºC

[ Exact Mass ]:
203.05600

[ PSA ]:
29.10000

[ LogP ]:
2.73680

[ Index of Refraction ]:
1.495

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AN3740000
CHEMICAL NAME :
m-Acetotoluidide, alpha,alpha,alpha-trifluoro-
CAS REGISTRY NUMBER :
351-36-0
BEILSTEIN REFERENCE NO. :
2213222
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-F3-N-O
MOLECULAR WEIGHT :
203.18
WISWESSER LINE NOTATION :
FXFFR CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,20,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

[ RTECS ]:
AN3740000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-(Trifluoromethyl)aniline
  • Ethanoic anhydride
  • Togni's Reagent
  • (3-Acetamidophenyl)boronic acid
  • allyl bromide
  • Acetanilide
  • Thioacetic acid
  • Acetamide, N-(4-chloro-3-(trifluoromethyl)phenyl)-
  • Acetyl chloride
  • Acetamide,N-[4-nitro-3-(trifluoromethyl)phenyl]-

DownStream

  • 2-(trifluoromethyl)acetanilide
  • Acetamide,N-[4-nitro-3-(trifluoromethyl)phenyl]-
  • N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide
  • N-[2-nitro-3-(trifluoromethyl)phenyl]acetamide
  • 3-(Trifluoromethyl)benzoic acid
  • 2,5-Diaminobenzo-Trifluoride
  • 2-Nitro-5-(trifluoromethyl)aniline
  • 5-Amino-2-nitrobenzotrifluoride
  • 2-Nitro-3-(trifluoromethyl)aniline
  • 4-bromo-3-(trifluoromethyl)acetanilide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 4-bromo-3-(trifluoromethyl)acetanilide
  • 3,5-bis(trifluoromethyl)acetanilide
  • 3-(trifluoromethyl)Azetidine,hydrochloride
  • 3-(trifluoromethyl)azetidine
  • 3-(Trifluoromethyl)cyclohexanecarboxylic acid
  • 3-trifluoromethyl-5-nitrophenylacetic acid ethyl ester
  • N-[1-(1H-indol-3-ylcarbonyl)piperidin-4-yl]pyridine-3-carboxamide
  • ethyl (2-{[(3-oxo-3,5,6,7,8,9-hexahydro-2H-cyclohepta[c]pyridazin-2-yl)acetyl]amino}-1,3-thiazol-4-yl)acetate
  • N-cyclopentyl-2-[3-(morpholin-4-yl)-6-oxopyridazin-1(6H)-yl]acetamide
  • 4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-N-[(2Z)-4-(pyridin-2-yl)-1,3-thiazol-2(3H)-ylidene]butanamide
  • 2-{2-[4-(3-methoxyphenyl)piperazino]-2-oxoethyl}-6-[4-(methylsulfanyl)phenyl]-3(2H)-pyridazinone
  • 4-[({[3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl]acetyl}amino)methyl]benzoic acid
  • 2-[3-(morpholin-4-yl)-6-oxopyridazin-1(6H)-yl]-N-(4-phenoxyphenyl)acetamide
  • N-(3-methylbutyl)-2-[3-(4-methylpiperidin-1-yl)-6-oxopyridazin-1(6H)-yl]acetamide
  • N-[(7,8-dimethoxy-1-oxophthalazin-2(1H)-yl)acetyl]glycine
  • N-[(2Z)-4-tert-butyl-1,3-thiazol-2(3H)-ylidene]-2-{3-[4-(methylsulfanyl)phenyl]-6-oxopyridazin-1(6H)-yl}acetamide
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