N-(2,2,2-trifluoroethyl)aniline

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Names

[ CAS No. ]:
351-61-1

[ Name ]:
N-(2,2,2-trifluoroethyl)aniline

[Synonym ]:
2,2,2-trifluoroethyl aniline
F9995-0049

Chemical & Physical Properties

[ Density]:
1.235g/cm3

[ Boiling Point ]:
186ºC at 760 mmHg

[ Molecular Formula ]:
C8H8F3N

[ Molecular Weight ]:
175.15100

[ Flash Point ]:
66.3ºC

[ Exact Mass ]:
175.06100

[ PSA ]:
12.03000

[ LogP ]:
2.73380

[ Index of Refraction ]:
1.489

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ0350000
CHEMICAL NAME :
Aniline, N-(2,2,2-trifluoroethyl)-
CAS REGISTRY NUMBER :
351-61-1
BEILSTEIN REFERENCE NO. :
2716921
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H8-F3-N
MOLECULAR WEIGHT :
175.17
WISWESSER LINE NOTATION :
FXFF1MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 2,184,1950
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00012

Safety Information

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2,2,2-Trifluoroethyl)phenyliodonium triflate
  • 2,2,2-Trifluoroethyltrifluoromethanesulfonate
  • N-(2,2,2-trifluoro-1-methoxyethyl)aniline
  • Trifluoroacetanilide
  • Methanol
  • N-methyl-N-(2,2,2-trifluoroethyl)aniline
  • N-Methyl-N-phenyltrifluoroacetamide
  • Trifluoracetaldehyd-phenylimin

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • N-ethyl-N-(2,2,2-trifluoroethyl)aniline
  • 3-Bromo-n-(2,2,2-trifluoroethyl)aniline
  • 4-Bromo-n-(2,2,2-trifluoroethyl)aniline
  • 4-chloro-N-(2,2,2-trifluoroethyl)aniline
  • 4-methyl-N-(2,2,2-trifluoroethyl)aniline
  • 2-methyl-N-(2,2,2-trifluoroethyl)aniline