Epoprostenol
Names
[ CAS No. ]:
35121-78-9
[ Name ]:
Epoprostenol
[Synonym ]:
PGX
Epoprostenol
MFCD00135629
Prostaglandin l2
prostacyclin
Vasocyclin
PGl2
ProstaglandinI
PGX(prostaglandin)
Cyclo-Prostin
EINECS 263-273-7
Prostaglandin X
Chemical & Physical Properties
[ Density]:
1.221g/cm3
[ Boiling Point ]:
530.2ºC at 760mmHg
[ Molecular Formula ]:
C20H31NaO5
[ Molecular Weight ]:
374.44700
[ Flash Point ]:
182.1ºC
[ Exact Mass ]:
374.20700
[ PSA ]:
89.82000
[ LogP ]:
2.07380
[ Index of Refraction ]:
1.611
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UK8008500
- CHEMICAL NAME :
- Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-
- CAS REGISTRY NUMBER :
- 35121-78-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H32-O5
- MOLECULAR WEIGHT :
- 352.52
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 15-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 33,193,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 800 ng/kg
- SEX/DURATION :
- female 1-4 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Maternal Effects - other effects
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 94,279,1992
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22;S26;S36