Norgestimate
Suppliers
Names
[ CAS No. ]:
35189-28-7
[ Name ]:
Norgestimate
[Synonym ]:
(3E,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
(+)-13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one Oxime Acetate (Ester)
d-17beta-acetoxy-13beta-ethyl-17alpha-ethinyl-gon-4en-3-one oxime
dexnorgestrelacetime
Norgestimat
Norgestimate
NORGESTIMATE,USP STANDARD
levonorgestrel acetate 3-oxime
(3E,8R,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylacetat
acétate de (3E,8R,9S,10R,13S,14S,17R)-13-éthyl-17-éthynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yle
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
497.9±45.0 °C at 760 mmHg
[ Melting Point ]:
216ºC
[ Molecular Formula ]:
C23H31NO3
[ Molecular Weight ]:
369.497
[ Flash Point ]:
254.9±28.7 °C
[ Exact Mass ]:
369.230408
[ PSA ]:
58.89000
[ LogP ]:
5.00
[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C
[ Index of Refraction ]:
1.611
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JF7976000
- CHEMICAL NAME :
- 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)-
- CAS REGISTRY NUMBER :
- 35189-28-7
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C23-H31-N-O3
- MOLECULAR WEIGHT :
- 369.55
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 2 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H361fd
[ Precautionary Statements ]:
P281-P305 + P351 + P338
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
63-22-36/38-62
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
JF7976000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Contraception 86(6) , 659-65, (2012)
We sought to estimate the prevalence of types of combined oral contraceptives (COCs) used among US women.We analyzed interview-collected data from 12,279 women aged 15-44 years participating in the Na...
J. Cell Sci. 127(Pt 19) , 4159-71, (2014)
The study aimed to investigate the effect of inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity on tau phosphorylation in HEK293/tau441 cells and its mechanism. HEK293/tau441 cells were tre...
Obstet. Gynecol. Clin. North Am. 21(2) , 299-319, (1994)
Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofa...