4-Hydroxy-6-methylpyrimidine

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Names

[ CAS No. ]:
3524-87-6

[ Name ]:
4-Hydroxy-6-methylpyrimidine

[Synonym ]:
6-Methylpyrimidin-4(1H)-one
6-METHYL-4-PYRIMIDINOL
4-hydroxy-6-Methyl-pyriMid
6-methylpyrimidine-4(3H)-one
6-methylpyrimidine-4-one
4(3H)-Pyrimidinone, 6-methyl-
4-Methylpyrimidine-6-ol
6-methyl-4(1h)-pyrimidinon
4-Pyrimidinol, 6-methyl-
6-methyl-4(3h)-pyrimidinon
6-Methyl-4-oxopyrimidine
4(1H)-pyrimidinone, 6-methyl-
4-Pyrimidinol,6-methyl
6-methyl-2-thiouracil
6-methylpyrimidin-4(3H)-one
6-Methyl-4(3H)-pyrimidinone
6-methyl-4-pyrimidino
6-methylpyrimidin-4-ol
4-oxo-6-methylpyrimidine
6-Methyl-4(1H)-pyrimidinone
4-Hydroxy-6-Methylpyrimidine
6-methyl-3H-pyrimidin-4-one
6-Methyl-pyrimidin-4-ol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
242.1±20.0 °C at 760 mmHg

[ Melting Point ]:
145-150℃

[ Molecular Formula ]:
C5H6N2O

[ Molecular Weight ]:
110.114

[ Flash Point ]:
100.2±21.8 °C

[ Exact Mass ]:
110.048012

[ PSA ]:
45.75000

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.557

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7528000
CHEMICAL NAME :
4(3H)-Pyrimidinone, 6-methyl-
CAS REGISTRY NUMBER :
3524-87-6
LAST UPDATED :
199406
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H5-N2-O
MOLECULAR WEIGHT :
109.12
WISWESSER LINE NOTATION :
T6N CNJ DQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 2,202,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
213 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 11,495,1963

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methylthiouracil
  • 4(1H)-Pyrimidinethione, 6-methyl- (9CI)
  • 2-(6-methylpyrimidin-4-yl)sulfanyl-1-phenylethanone
  • 1-(4-methylphenyl)-2-(6-methylpyrimidin-4-yl)sulfanylethanone
  • 1-(4-chlorophenyl)-2-(6-methylpyrimidin-4-yl)sulfanylethanone
  • 1-(4-bromophenyl)-2-(6-methylpyrimidin-4-yl)sulfanylethanone
  • 1-(4-methoxyphenyl)-2-(6-methylpyrimidin-4-yl)sulfanylethanone
  • 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one
  • 2,4-Dichloro-6-methylpyrimidine

DownStream

  • 4-Hydroxy-6-methylpyrimidine
  • 6-ethyl-5-iodo-1H-pyrimidin-4-one
  • 5-Bromo-4-chloro-6-methylpyrimidine
  • 5-bromo-6-methylpyrimidin-4-ol
  • 4-Chloro-6-methylpyrimidine
  • 4,5-Dichloro-6-methylpyrimidine
  • 3,6-dimethylpyrimidin-4-one
  • 5-bromo-6-methylpyrimidine-4-carbonitrile
  • 4-Chloro-5-iodo-6-methylpyrimidine
  • 1-(4-chlorophenyl)-2-(6-methylpyrimidin-4-yl)sulfanylethanone

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-HYDROXY-6-METHYLPYRIMIDINE
  • 5-CYANO-4-HYDROXY-6-METHYLPYRIMIDINE
  • 2-Amino-4-hydroxy-6-methylpyrimidine
  • 2-Ethoxy-4-hydroxy-6-methylpyrimidine
  • 4-Hydroxy-6-methylpyrimidine-2(1H)-thione
  • 2-tert-butyl-4-hydroxy-6-methylpyrimidine