bromochlorodifluoromethane

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Names

[ CAS No. ]:
353-59-3

[ Name ]:
bromochlorodifluoromethane

[Synonym ]:
BROMOCHLORODIFLUOROMETHANE
chlorobromodifluoromethane
monobromomonochlorodifluoromethane
Acetic acid,bromochloro-,methyl ester
chloro-bromo-acetic acid methyl ester
difluorobromochloromethane
EINECS 206-537-9
difluorochlorobromomethane
bromo-chloro-difluoromethane
Brom-chlor-essigsaeure-methylester
bromo-chloro-acetic acid methyl ester

Chemical & Physical Properties

[ Density]:
1.85

[ Boiling Point ]:
-3,7ºC

[ Melting Point ]:
-160.5ºC

[ Molecular Formula ]:
CBrClF2

[ Molecular Weight ]:
165.36500

[ Exact Mass ]:
163.88400

[ LogP ]:
2.17040

[ Index of Refraction ]:
1.4

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PA5270000
CHEMICAL NAME :
Methane, bromochlorodifluoro-
CAS REGISTRY NUMBER :
353-59-3
BEILSTEIN REFERENCE NO. :
1732514
LAST UPDATED :
199801
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C-Br-Cl-F2
MOLECULAR WEIGHT :
165.37
WISWESSER LINE NOTATION :
GXFFE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
4 pph/1M
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Behavioral - hallucinations, distorted perceptions Cardiac - EKG changes not diagnostic of specified effects
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 pph/15M
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
5 pph/30M
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
30 pph/2H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 ug/m3/4H/12W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 pph/6H/3W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
10 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 142,187,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1000 mg/m3 JAN 1993

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
23-36/37/39

[ RIDADR ]:
UN 1974

[ Hazard Class ]:
2.2

[ HS Code ]:
2903760010

Synthetic Route

Precursor & DownStream

Precursor

  • Difluorochloromethane
  • Bromine
  • 1,3-dichlorotetrafluoroacetone
  • Bromodifluoromethane (HCFC-22B1)
  • silver(1+) chlorodifluoroacetate
  • Hydrochloric acid
  • Dibromodifluoromethane
  • Chlorine
  • Dichlorodifluoromethane

DownStream

  • (4-bromo-4,4-difluorobut-2-ynoxy)-tert-butyl-dimethylsilane
  • 3-bromoprop-2-ynoxy-tert-butyl-dimethylsilane
  • Bromodifluoromethane (HCFC-22B1)
  • Difluoromethane
  • Bromofluoromethane
  • Dichloromethane
  • Difluorochloromethane
  • Dibromomethane
  • Dichlorodifluoromethane
  • Bromine

Customs

[ HS Code ]: 2903760010

[ Summary ]:
2903760010 bromochlorodifluoromethane。supervision conditions:14abxy。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%