Honokiol

Suppliers

Names

[ Name ]:
Honokiol

[Synonym ]:
3',5-Di-2-propenyl-[1,1'-biphenyl]-2,4'-diol
5,3'-DIALLYL-2,4'-DIHYDROXYBIPHENYL
3,3'-DIALLYL-4,6'-DIHYDROXYBIPHENYL
HONEYSUCKLEFLOWEREXTRACT
5,3'-diallyl-biphenyl-2,4'-diol
Honokiol
[1,1'-Biphenyl]-2,4'-diol, 3',5-di-2-propen-1-yl-
2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol
3',5-Diallyl-2,4'-dihydroxybiphenyl
5,3'-DIALLYL-2,4'-DIHYDROXYDIPHENYL
MFCD00016674
3',5-Diallylbiphenyl-2,4'-diol
5,5'-diallyl-2,4'-dihydroxybiphenyl
3',5-Diallyl-2,4'-biphenyldiol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
400.1±40.0 °C at 760 mmHg

[ Melting Point ]:
87.5ºC

[ Molecular Formula ]:
C₁₈H₁₈O₂

[ Molecular Weight ]:
266.334

[ Flash Point ]:
184.0±21.9 °C

[ Exact Mass ]:
266.130676

[ PSA ]:
40.46000

[ LogP ]:
4.20

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 36 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R41;R51/53

[ Safety Phrases ]:
S26-S39-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ Hazard Class ]:
9.0

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-(2-methoxy-5-prop-2-enylphenyl)-2-prop-2-enylphenol
3',5-diallyl-2,4'-bis(methoxymethoxy)-1,1'-biphenyl
5'-allyl-4-allyloxy-2'-hydroxybiphenyl
4-O-Methyl honokiol
5-allyl-4'-(allyloxy)-2-methoxybiphenyl
5-Bromo-2-hydroxybenzoic acid
Methyl 3-bromo-4-hydroxybenzoate
Methyl 5-Bromosalicylate
Methyl 4-hydroxybenzoate

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.

Biomed. Pharmacother. 70 , 140-5, (2015)

Drug efflux transporter P-glycoprotein plays an important role in cancer chemotherapy. The nuclear factor-κB (NF-κB) transcription factors play critical roles in development and progression of cancer....

Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations

J. Chromatogr. A. 1344 , 51-8, (2014)

• Impurity separation of honokiol and quercetin by both preparative HPLC and CCC. • Several performance parameters of separation were compared. • CCC provided larger sample loading, especially for a s...

Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.

Biochim. Biophys. Acta 1840(10) , 3017-21, (2014)

Magnolia bark preparations from Magnolia officinalis of Asian medicinal systems are known for their muscle relaxant effect and anticonvulsant activity. These CNS related effects are ascribed to the pr...