Pyrvinium pamoate
Suppliers
Names
Chemical & Physical Properties
[ Density]:
1.0104 (rough estimate)
[ Boiling Point ]:
829.27°C (rough estimate)
[ Melting Point ]:
210-215° (softens at 190°)
[ Molecular Formula ]:
C26H28N3.1/2C23H14O6
[ Molecular Weight ]:
575.70
[ PSA ]:
144.82000
[ LogP ]:
12.33840
[ Appearance of Characters ]:
red
[ Index of Refraction ]:
1.6400 (estimate)
[ Storage condition ]:
room temp
[ Water Solubility ]:
DMSO: >10mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC3543500
- CAS REGISTRY NUMBER :
- 3546-41-6
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C75-H70-N6-O6
- MOLECULAR WEIGHT :
- 1151.51
- WISWESSER LINE NOTATION :
- T66 BKJ B1 HN1&1 C1U1- CT5NJ AR& B1 E1 &L66J CQ DVO B1- BL66J CQ DVO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 gm/kg/30D-C
- TOXIC EFFECTS :
- Endocrine - other changes Related to Chronic Data - death Related to Chronic Data - changes in testicular weight
MUTATION DATA
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 400 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,79,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81965 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81965 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 774 (estimated) No. of Female Employees: 337 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351
[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330-P305 + P351 + P338
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
20/21/22-36/37/38-40
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
Articles
J. Neurosci. 34(17) , 6030-9, (2014)
Repressor Element-1 (RE1) Silencing Transcription Factor/Neuron-Restrictive Silencer Factor (REST/NRSF) is a gene-silencing factor that is widely expressed during embryogenesis and plays a strategic r...