Menbutone

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Names

[ CAS No. ]:
3562-99-0

[ Name ]:
Menbutone

[Synonym ]:
menbutone
ido-genabil
naftobil
epanaftol
genabil
genabilin
menbuton
Icteryl
3-(4-Methoxy-1-Naphthoyl)Propionic Acid
fel-bis

Chemical & Physical Properties

[ Density]:
1.249 g/cm3

[ Boiling Point ]:
511.5ºC at 760 mmHg

[ Molecular Formula ]:
C15H14O4

[ Molecular Weight ]:
258.26900

[ Flash Point ]:
196.6ºC

[ Exact Mass ]:
258.08900

[ PSA ]:
63.60000

[ LogP ]:
2.89590

[ Index of Refraction ]:
1.629

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UF5276000
CHEMICAL NAME :
Propionic acid, 3-(4-methoxy-1-naphthoyl)-
CAS REGISTRY NUMBER :
3562-99-0
BEILSTEIN REFERENCE NO. :
3059815
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C15-H14-O4
MOLECULAR WEIGHT :
258.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958

Synthetic Route

Precursor & DownStream

Precursor

  • Succinic anhydride
  • 1-Methoxynapthalene
  • 1-Naphthalenol
  • 4-(4-hydroxy-[1]naphthyl)-4-oxo-butyric acid
  • Dimethyl sulfate
  • Carbon disulphide
  • Aluminium chloride
  • tetrachloroethane
  • nitrobenzene

DownStream

  • 1-Naphthalenebutanoicacid, 4-methoxy-
  • 4,4'-Bi[1-naphthol]
  • 4-(4-hydroxynaphthalen-1-yl)butanoic acid
  • 1-methoxy-4-(4-methoxynaphthalen-1-yl)naphthalene
  • ethyl 4-(4-methoxynaphthalen-1-yl)-4-oxo-butanoate

Related Compounds

  • menbutone
  • Menbutone magnesium salt