10,11-Dihydrocarbamazepine
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Names
[ CAS No. ]:
3564-73-6
[ Name ]:
10,11-Dihydrocarbamazepine
[Synonym ]:
10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine
10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin
10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine
GP 26-301
10,11-DIHYDROCARBAMAZEPINE
EINECS 222-649-0
10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide
10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide
MFCD00005072
10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide
10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO
5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
394.5±52.0 °C at 760 mmHg
[ Melting Point ]:
205-210ºC
[ Molecular Formula ]:
C15H14N2O
[ Molecular Weight ]:
238.28
[ Flash Point ]:
192.4±30.7 °C
[ Exact Mass ]:
238.110611
[ PSA ]:
46.33000
[ LogP ]:
2.60
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.645
[ Storage condition ]:
Refrigerator
[ Water Solubility ]:
dichloromethane: soluble2.5%, clear, colorless | Soluble in dichloromethane. Insoluble in water.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HN8300000
- CHEMICAL NAME :
- 5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-
- CAS REGISTRY NUMBER :
- 3564-73-6
- BEILSTEIN REFERENCE NO. :
- 0196969
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H14-N2-O
- MOLECULAR WEIGHT :
- 238.31
- WISWESSER LINE NOTATION :
- T C676 BN&T&J BVZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H317-H334
[ Precautionary Statements ]:
P261-P280-P342 + P311
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-42/43
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
HN8300000
[ HS Code ]:
2933990090
Synthetic Route
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Eur. J. Biochem. 267(1) , 110-20, (2000)
Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the str...
J. Assoc. Off. Anal. Chem. 70(5) , 836-40, (1987)
Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and table...
Acta Crystallogr. C 62(Pt 5) , o240-2, (2006)
The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The mo...