Galantamine

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Names

[ CAS No. ]:
357-70-0

[ Name ]:
Galantamine

[Synonym ]:
MFCD00867189
3,4-Dihydrogalanthamine
Galantamine
Nivalin
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-
Lycoremine
Galantamine Hydrobromide
(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Galanthamine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
439.3±45.0 °C at 760 mmHg

[ Melting Point ]:
119-121ºC

[ Molecular Formula ]:
C₁₇H₂₁NO₃

[ Molecular Weight ]:
287.353

[ Flash Point ]:
219.5±28.7 °C

[ Exact Mass ]:
287.152130

[ PSA ]:
41.93000

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW5952100

CHEMICAL NAME :: Galanthamine

CAS REGISTRY NUMBER :: 357-70-0

BEILSTEIN REFERENCE NO. :: 0093736

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H21-N-O3

MOLECULAR WEIGHT :: 287.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5177082

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 37,689,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4550113

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Galanthaminone
N-formyl-N-norgalanthamine
(-)-isogalanthamine
(4aR,6S,8aR)-4a,5,11,12-tetrahydro-6-hydroxy-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]-benzazepin-10(9H)-one
Galantamine hydrobromide
(2S,5R)-5-benzyl-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]imidazolidin-4-one
(4aS,8aS,13R,14aR)-13-benzyl-2-hydroxy-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-6,12(13H)-dione
(4aS,8aS,13R,14aR)-13-benzyl-3-methoxy-6,12-dioxo-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,12,13,14,14a-octahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepin-2-yl trifluoromethanesulfonate
(2R,11bR)-2-benzyl-8,10-bis(benzyloxy)-9-methoxy-1-(2,2,2-trifluoroacetyl)-1,5,6,11b-tetrahydrospiro[benzo[c]imidazo[1,2-a]azepine-7,1'-cyclohexane]-2',5'-diene-3,4'(2H)-dione
(2S,5R)-5-benzyl-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

DownStream

Customs

[ HS Code ]: 2942000000