Ethanol, 2-chloro-,1-methanesulfonate

Suppliers

Names

[ Name ]:
Ethanol, 2-chloro-,1-methanesulfonate

[Synonym ]:
2-Chloroethylmethanesulfonate
2-Chloroethyl Methanesulfonate
2-Chloroethyl methanesulphonate
Methanesulfonic acid,2-chloroethyl ester
2-chloroethyl mesylate
2-Chlorethylmesylat
EINECS 222-672-6
CB 1506
Chloroethyl methanesulfonate
2-Chloroethylmethanesulfonate,puriss
Methanesulfonic Acid 2-Chloroethyl Ester
MFCD00007560
Chloroethyl methanesulphonate

Chemical & Physical Properties

[ Density]:
1.39 g/mL at 25ºC(lit.)

[ Boiling Point ]:
125-126ºC9 mm Hg(lit.)

[ Melting Point ]:
6ºC

[ Molecular Formula ]:
C₃H₇ClO₃S

[ Molecular Weight ]:
158.60400

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
157.98000

[ PSA ]:
51.75000

[ LogP ]:
1.28220

[ Index of Refraction ]:
n20/D 1.456(lit.)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK1960000

CHEMICAL NAME :: Ethanol, 2-chloro-, methanesulfonate

CAS REGISTRY NUMBER :: 3570-58-9

BEILSTEIN REFERENCE NO. :: 1754022

LAST UPDATED :: 199612

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C3-H7-Cl-O3-S

MOLECULAR WEIGHT :: 158.61

WISWESSER LINE NOTATION :: WS1&O2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 127 mg/kg

TOXIC EFFECTS :: Behavioral - coma Liver - other changes Tumorigenic - tumors at site of application

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 25 mg/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Mold - Neurospora crassa

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MGBUA3 Microbial Genetics Bulletin. (Ohio State Univ., College of Biological Science, Dept. of Microbiology, 484 W. 12th Ave., Columbus, OH 43210) No.1- 1950- Volume(issue)/page/year: 17,5,1960

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S23;S45;S36/S37/S39

[ RIDADR ]:
UN 2810 6

[ WGK Germany ]:
3

[ RTECS ]:
KK1960000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methanesulfonyl chloride
2-Chloroethanol
Methanesulfonic acid
1-Dodecyne
dichloroethane
N,N-dibenzylpent-4-ynylamine
ethene
TETRABUTYLAMMONIUM METHANESULFONATE
ETHYLENE OXIDE
methanesulfonyl fluoride

DownStream

1-(2-Chloroethoxy)-4-methoxybenzene
1,3-Dibromo-2-(2-chloroethoxy)benzene
1-chloro-2-fluoroethane
Thiocyanic acid,2-chloroethyl ester

Articles

Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.

Mutat. Res. 331(2) , 213-24, (1995)

The 2-chloroethyl methanesulfonate (2ClEMS)-induced alcohol dehydrogenase (Adh) null germline mutation frequency in treated Drosophila melanogaster second instar larval gonia was two orders of magnitu...

Ethanol, 2-chloro-,1,1'-sulfate
Ethanol, 2-chloro-1-(3-methyl-6-methylene-2,4-cyclohexadien-1-ylidene)-, (E)- (9CI)
Ethanol, 2-chloro-,1,1'-carbonate
Ethanol, 2-chloro-1-(3-methyl-6-methylene-2,4-cyclohexadien-1-ylidene)-, (Z)- (9CI)
2-chloro-1-methoxyethanol
2-chloro-1-(2-naphthyl)ethanol
4-(4-chloro-3,5-dimethyl-phenoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]butanamide
4-[8-[2-Azidoethyl(methyl)amino]octoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
(2S,4R)-1-[(2S)-3,3-dimethyl-2-(prop-2-enoylamino)butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
12-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]-12-oxo-dodecanoic acid
13-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]tridecanoic acid
2-[5-(4-amino-1-piperidyl)pentoxy]-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]acetamide
2-(4-bromophenoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide
8-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]-N-[(2S)-2-hydroxybutyl]octanamide
8-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]-N-[(1R)-3-hydroxy-1-methyl-propyl]octanamide
(2R,4S)-1-[(2S)-2-[(2-aminoacetyl)amino]-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.