Carboprost

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Names

[ CAS No. ]:
35700-23-3

[ Name ]:
Carboprost

[Synonym ]:
prostin15m
Methyl-pgf2a
(15S)-15-Methylprostaglandin F2α
(E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-3-methyl-1-octenyl))cyclopentyl)-5-heptenoic acid
15s)-13e
15-Methyl-PGF2a
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9α,11α,13E,15S)-
15-ME-PGF2a
methyldinoprost
(5Z,9a,11a,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic Acid
(15S)-15-Methyl-PGF2a
Carboprost
(15S)-15-Methyl PGF2a
(15S)-15-Methylprostaglandin F2a
15-methyl-15S-PGF2α
(5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic acid
MFCD00135249

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
536.6±50.0 °C at 760 mmHg

[ Melting Point ]:
79-82ºC

[ Molecular Formula ]:
C21H36O5

[ Molecular Weight ]:
368.508

[ Flash Point ]:
292.4±26.6 °C

[ Exact Mass ]:
368.256287

[ PSA ]:
97.99000

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.565

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8021000
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9-alpha,11-alpha,13E,15S)-
CAS REGISTRY NUMBER :
35700-23-3
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C21-H36-O5
MOLECULAR WEIGHT :
368.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
5 ug/kg
SEX/DURATION :
female 14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
12 ug/kg
SEX/DURATION :
female 30 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 14,785,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraplacental
DOSE :
10 ug/kg
SEX/DURATION :
female 13 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
60 ug/kg
SEX/DURATION :
female 42 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 21,273,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
10 ug/kg
SEX/DURATION :
female 15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
100 ug/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,540,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
500 ug/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 151,575,1976 *** REVIEWS *** TOXICOLOGY REVIEW AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 113,130,1972

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36:Irritating to the eyes.

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
2

[ RTECS ]:
TU0175000

Precursor & DownStream

Precursor

  • (15S)-15-methyl-PGF2α 1,11-lactone 9,15-bis(tert-butyldimethylsilyl ether)
  • (15S)-15-methyl-PGF2α methyl ester 11-(trichloroethylcarbonate)
  • (15S)-15-methyl-PGF2α methyl ester 9,15bis(tert-butyldimethylsilyl ether)
  • (15S)-15-methyl-PGF2α methyl ester 9,15bis(tert-butyldimethylsilyl ether) 11-(trichloroethyl carbonate)

DownStream

  • 15(S)-15-methyl Prostaglandin D2

Related Compounds

  • carboprost
  • Carboprost
  • trans-Carboprost
  • Carboprost Methyl
  • Carboprost methylate
  • Carboprost trometamol
  • 7-[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylethyl]-3-methyl-8-morpholin-4-yl-4,5-dihydropurine-2,6-dione
  • 1-(3-hydroxyphenyl)-6,7-dimethyl-2-(6-methylpyridin-2-yl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 2-(2-oxooxolan-3-yl)sulfanyl-4aH-quinazolin-4-one
  • 6-benzyl-3-(4-fluorophenyl)-2,5-dimethyl-2,3,3a,4-tetrahydro-1H-pyrazolo[1,5-a]pyrimidin-7-one
  • (4-Chlorophenyl)methyl-(1,3-dimethyl-2,6-dioxopurin-8-ylidene)azanium
  • 8-[(2-chlorophenyl)methylamino]-7-[(4-fluorophenyl)methyl]-1,3-dimethyl-5H-purin-7-ium-2,6-dione
  • 8-[2-(4-fluorophenyl)ethylamino]-7-[(4-fluorophenyl)methyl]-1,3-dimethyl-5H-purin-7-ium-2,6-dione
  • 1-(1,3-Dimethyl-2,6-dioxopurin-8-ylidene)piperidin-1-ium-4-carboxylic acid
  • N-(3-Amino-2-cyclopropoxyphenyl)methanesulfonamide
  • 3-Cyclopropoxy-6-methylpyridine-2-sulfonamide
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