l-3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-N-FORMYLALANINE

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Names

[ CAS No. ]:
35849-41-3

[ Name ]:
l-3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-N-FORMYLALANINE

[Synonym ]:
N-Formyl-L-p-sarcolysin

Chemical & Physical Properties

[ Density]:
1.331g/cm3

[ Boiling Point ]:
580.1ºC at 760mmHg

[ Molecular Formula ]:
C14H18Cl2N2O3

[ Molecular Weight ]:
333.21000

[ Flash Point ]:
304.6ºC

[ Exact Mass ]:
332.06900

[ PSA ]:
69.64000

[ LogP ]:
2.73910

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY3850000
CHEMICAL NAME :
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, L-
CAS REGISTRY NUMBER :
35849-41-3
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H18-Cl2-N2-O3
MOLECULAR WEIGHT :
333.24
WISWESSER LINE NOTATION :
QVYMVH1R DN2G2G -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 20,144,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 20,144,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 20,144,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 20,144,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • melphalan
  • Formic Acid

DownStream

Related Compounds

  • 3-Amino-1-(pentan-2-yl)-1,2-dihydropyridin-2-one
  • rac-(3R,4R)-4-(cyclopropylmethyl)pyrrolidin-3-amine
  • 1-[2-(chloromethyl)phenyl]-4-methanesulfonyl-1H-pyrazole
  • 2,5-Dimethyl-3-(pyridin-2-yl)aniline
  • 2-(3-ethylcyclohexyl)-2H-1,2,3-triazol-4-amine
  • 1-(4-methanesulfonyl-1H-pyrazol-1-yl)pentan-2-ol
  • 4-(3-Acetylphenyl)morpholin-3-one
  • [5-(1-methyl-1H-imidazol-4-yl)-1,2-oxazol-3-yl]methanethiol
  • [5-(1-ethyl-1H-1,2,3-triazol-4-yl)-1,2-oxazol-3-yl]methanethiol
  • 4-methoxy-2-methyl-1-(1H-pyrazol-4-yl)butan-1-ol
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