17beta-Estradiol 3-tetrahydropyranyl ether

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Names

[ CAS No. ]:
3589-90-0

[ Name ]:
17beta-Estradiol 3-tetrahydropyranyl ether

[Synonym ]:
17beta-Estradiol 3-tetrahydropyranyl ether
RS-2290

Chemical & Physical Properties

[ Density]:
1.16g/cm3

[ Boiling Point ]:
508.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₂O₃

[ Molecular Weight ]:
356.49800

[ Flash Point ]:
261.5ºC

[ Exact Mass ]:
356.23500

[ PSA ]:
38.69000

[ LogP ]:
5.16010

[ Index of Refraction ]:
1.585

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7742000

CHEMICAL NAME :: Estra-1,3,5(10)-trien-3-ol, 17-beta-(tetrahydro-2H-pyran-2-yloxy)-

CAS REGISTRY NUMBER :: 3589-90-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H32-O3

MOLECULAR WEIGHT :: 356.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 26400 ng/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 20,211,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 20,211,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1500 ug/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 20,211,1969

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-O-(tert-butyldimethylsilyl)-17β-O'-(tetrahydropyranyl)-19-oxoandrosta-2,4-diene-3,17β-diol
3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene
3,4-Dihydro-2H-pyran
3β,19-Dihydroxyandrost-5-en-17-one
17β-O-(tetrahydropyranyl)androst-5-ene-3β,17β,19-triol
3β,19-O,O'-diacetylandrost-5-ene-3β,17β,19-triol
3β,19-O,O'-diacetyl-17β-O''-(tetrahydropyranyl)androst-5-ene-3β,17β,19-triol
beta-Estradiol
Nandrolone

DownStream

Related Compounds

17beta-Estradiol 3-Methyl Ether
3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5-trien-6α-ol
Estra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)-
17β-Estradiol 3-β-D-Glucuronide
24-phenylsulphonylchol-5-en-3β-ol 3-tetrahydropyranyl ether
3β-hydroxy-5-androsten-17-one 3-tetrahydropyranyl ether
(3R)-3-Methyltetrahydrofuran-3-carboxylic acid
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
6-methyl-N-(2-(2-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)ethyl)nicotinamide
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
4-(3-Chlorophenyl)-5-(methylsulfonyl)-1,2,3-thiadiazole