Triciribine

Suppliers

Names

[ CAS No. ]:
35943-35-2

[ Name ]:
Triciribine

[Synonym ]:
triciribine
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-
UNII-2421HMY9N6
5-Methyl-1-(β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacennaphthylen-3-amine
5-Methyl-1-b-D-ribofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
API-2 Akt/PKB Signaling Inhibitor-2 Inhibitor V

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
718.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H16N6O4

[ Molecular Weight ]:
320.304

[ Flash Point ]:
388.3±35.7 °C

[ Exact Mass ]:
320.123291

[ PSA ]:
144.47000

[ LogP ]:
-2.70

[ Appearance of Characters ]:
tan

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.928

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
DMSO: >10mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RY8455000
CHEMICAL NAME :
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
35943-35-2
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H16-N6-O4
MOLECULAR WEIGHT :
320.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
199 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,6355,1985

Safety Information

[ RTECS ]:
RY8455000

Precursor & DownStream

Precursor

  • 4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine
  • b-D-Ribofuranose 1-acetate 2,3,5-tribenzoate
  • 6-bromo-4-chloro-5-cyano-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine
  • 6-bromo-5-cyano-4-(1-methylhydrazino)-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine
  • 6-bromo-4-chloro-5-cyanopyrrolo[2,3-d]pyrimidin-4-one
  • 6-Bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • 4-amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • 4-(N-methyl-hydrazino)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

DownStream

Related Compounds

  • triciribine phosphate
  • N-(1H-indol-5-yl)-3-{4-methyl-7-[(2-methyl-2-propenyl)oxy]-2-oxo-2H-chromen-3-yl}propanamide
  • 8-Chloro-9-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3A-aza-phenalene-5-carboxylic acid
  • 4-Amino-1-(5-deoxy-I(2)-D-arabinofuranosyl)-2(1H)-pyrimidinone
  • 1-(Cyclopropylmethyl)-7-methoxy-4-phenyl-2(1H)-quinazolinethione
  • 4-[(3,4-Dichlorophenyl)methoxy]piperidine
  • 5-Bromo-7-chloro-quinolin-8-ol
  • 2,4-Pentadienoic acid, 5-(2,6-dichlorophenyl)-, (Z,E)-
  • 4-Oxo-4,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbaldehyde
  • 1-Methyl-1H-benzofuro[3,2-b]pyrrole-2-carboxylic acid
  • 7-Phenyl-5H-[1,2,4]triazolo[5,1-b][1,3]thiazin-5-imine
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