GLYCODEOXYCHOLIC ACID

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Names

[ CAS No. ]:
360-65-6

[ Name ]:
GLYCODEOXYCHOLIC ACID

[Synonym ]:
Glycodeoxycholic acid monohydrate
Glycodeoxycholic acid
MFCD00150922

Chemical & Physical Properties

[ Density]:
1.162 g/cm3

[ Boiling Point ]:
655.6ºC at 760 mmHg

[ Molecular Formula ]:
C26H45NO6

[ Molecular Weight ]:
467.63900

[ Flash Point ]:
350.3ºC

[ Exact Mass ]:
467.32500

[ PSA ]:
116.09000

[ LogP ]:
3.92070

[ Index of Refraction ]:
1.546

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9670000
CHEMICAL NAME :
Glycine, N-(3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-yl)-
CAS REGISTRY NUMBER :
360-65-6
LAST UPDATED :
198803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C26-H43-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,323,1970

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MB9670000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Glycine
  • Deoxycholic acid
  • Cholan-24-oic acid,3,12-bis(formyloxy)-, (3a,5b,12a)-
  • 3α,12α-diformyloxy-5β-cholan-24-oic acid chloride

DownStream

Articles

Photophysical and photodynamical study of fluoroquinolone drug molecule in bile salt aggregates.

Photochem. Photobiol. 88 , 1248, (2012)

Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Exp...

Quantification of cholesterol solubilized in bile salt micellar aqueous solutions using13C nuclear magnetic resonance

Anal. Biochem. 427(1) , 41-8, (2012)

In this work, we develop a methodology to quantitatively follow the solubilization of cholesterol on glycodeoxycholic acid (GDCA) micelles using 13C nuclear magnetic resonance (NMR). The amount of sol...

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J. Surg. Res. 193(1) , 161-7, (2015)

The effects of the glutamine on the acute pancreatitis are controversial in the clinical and experimental studies. The aim of this study was to investigate the influence of glutamine alone on acute ne...


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Related Compounds

  • Glycodeoxycholic Acid-d4
  • Glycodeoxycholic Acid-d6
  • Glycodeoxycholic acid sodium salt
  • Glycodeoxycholic acid monohydrate
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  • Hexanethioic acid S-decyl ester
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