5-Amino-4-imidazolecarboxamide

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Names

[ CAS No. ]:
360-97-4

[ Name ]:
5-Amino-4-imidazolecarboxamide

[Synonym ]:
4-AMino-5-carbaMoyliMidazole
4(5)-aminoimidazole-5(4)-carboxamide
5-aminoimidazole-4-carboxamide
diazol-c
5-amino-4-imidazole carboxamide
4-Amino-5-imidazolecarboxamide
T5M CNJ DVZ EZ
MFCD02181040
EINECS 206-641-4
4-aminoimidazole-5-carboxamide
ba2756
1H-Imidazole-4-carboxamide, 5-amino-
5-Amino-4-imidazolecarboxamide
aminoimidazolecarboxamide
4-amino-5-imidazolecarboxamid
4-Amino-5-imodazole
aic
4-Aminoimidzole-5-carboxamide
5-Amino-Imidazole-4-carboxamide
5-amino-1H-imidazole-4-carboxamide
4-Amino-1H-imidazole-5-carboxamide
T5M CNJ DZ EVZ
1H-Imidazole-4-carboximidic acid, 5-amino-
5-AMINO-1H-IMIDAZOLE 4-CARBOXAMIDE
Dacarbazine Impurity 2

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
535.4±60.0 °C at 760 mmHg

[ Melting Point ]:
164-170 °C(lit.)

[ Molecular Formula ]:
C4H6N4O

[ Molecular Weight ]:
126.117

[ Flash Point ]:
277.6±32.9 °C

[ Exact Mass ]:
126.054161

[ PSA ]:
97.79000

[ LogP ]:
-1.01

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.799

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI3910000
CHEMICAL NAME :
Imidazole-4-carboxamide, 5-amino-
CAS REGISTRY NUMBER :
360-97-4
LAST UPDATED :
199806
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C4-H6-N4-O
MOLECULAR WEIGHT :
126.14
WISWESSER LINE NOTATION :
T5M CNJ DVZ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22750 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2275 mg/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6390 mg/kg/21W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - rat Cells - not otherwise specified
DOSE/DURATION :
3 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NI3910000

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

  • 3-benzyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  • 4(5)-oxoimidazole-5(4)-carbonitrile
  • Acadesine (AICAR)
  • Methanimidic acid,N-(2-amino-1-cyano-2-oxoethyl)-, ethyl ester
  • Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3-(2-chloroethyl)-3,4-dihydro-4-oxo-
  • 3-Amino-2-(formylamino)-3-iminopropanamide
  • Formimidamide hydrochloride
  • 3-Nitriloalaninamide
  • Sulfuric acid

DownStream

  • 2-Azahypoxanthine
  • 6-chloro-2-(trifluoromethyl)-5H-purine
  • 5-Amino-1H-imidazole-4-carboxamide hydrochloride
  • 5-Diazoimidazole-4-carboxamide
  • Aica ribonucleotide
  • Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3-(2-chloroethyl)-3,4-dihydro-4-oxo-
  • 2,6-Dihydroxypurine
  • 2-oxo-3,4-dihydro-1H-imidazo[1,5-a]pyrimidine-8-carboxamide
  • 4-(benzoylcarbamothioylamino)-1H-imidazole-5-carboxamide
  • Ethyl 4-amino-1H-imidazole-5-carboxylate

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 5-Amino-4-imidazolecarboxamide hydrochloride
  • 5-Amino-4-imidazolecarboxamide hydrochloride
  • 5-amino-4-(methoxymethyl)-6-methyl-3-pyridinemethanamine
  • 5-amino-4,6-dichloro-toluene-2-sulfonic acid amide
  • 5-Amino-4-methylpyrimidine
  • 5-Amino-4-chloro-2-fluoro-benzoic acid Methyl ester
  • 8-Oxo-2,7-diazaspiro[3.5]nonane-5-carboxylic acid
  • 3-(3-{[(tert-butoxy)carbonyl]amino}-N-methylpropanamido)propanoic acid
  • 3-(2-{[(Tert-butoxy)carbonyl]amino}propoxy)benzoic acid
  • 3-(2-{[(Tert-butoxy)carbonyl]amino}propoxy)-5-chlorobenzoic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-5-carboxylic acid
  • Methyl 3-[1-(aminomethyl)cyclobutyl]prop-2-ynoate
  • 3-[1-(Aminomethyl)cyclobutyl]prop-2-ynoic acid
  • N-{6,6-difluorospiro[3.3]heptan-2-yl}benzamide
  • [(5-Aminohexyl)carbamoyl]formicacidhydrochloride
  • Methyl 3-[(2-aminocyclopentyl)sulfanyl]propanoate hydrochloride
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