UNII:6LL60J9E0O
Suppliers
Names
[ CAS No. ]:
3614-69-5
[ Name ]:
UNII:6LL60J9E0O
[Synonym ]:
Fenistil-retard
N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1)
Fenistil
Forthistal maleate
1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1)
Dimethinden maleate
Forhistal maleate
Dimethpyrindene maleate
Dimethindene maleate
Dimetindene maleate
UNII:6LL60J9E0O
SU-6518
3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1)
N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1)
dimetindene hydrogen maleate
Chemical & Physical Properties
[ Boiling Point ]:
416.3ºC at 760mmHg
[ Melting Point ]:
159-161℃
[ Molecular Formula ]:
C24H28N2O4
[ Molecular Weight ]:
408.490
[ Flash Point ]:
205.6ºC
[ Exact Mass ]:
408.204895
[ PSA ]:
90.73000
[ LogP ]:
3.85850
[ Water Solubility ]:
Slightly soluble in water, soluble in methanol
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT0830000
- CAS REGISTRY NUMBER :
- 3614-69-5
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H24-N2.C4-H4-O4
- MOLECULAR WEIGHT :
- 408.54
- WISWESSER LINE NOTATION :
- L56 BHJ C2N1&1 DY1&- BT6NJ &QV2VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 618 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 888 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961
Safety Information
[ Hazard Codes ]:
Xn
[ HS Code ]:
2933399090
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Drug Dev. Ind. Pharm. 33(11) , 1199-204, (2007)
Cyclodextrin-mediated capillary isotachophoresis (ITP) in cationic regime of the separation was developed for the separation and quantitation of alkylamine antihistamine dimethindene (DIM) and phenira...
Bioorg. Med. Chem. Lett. 20(19) , 5874-8, (2010)
Analogs of the known H(1)-antihistamine R-dimethindene with suitable selectivity for key GPCRs, P450 enzymes and hERG channel were assessed for metabolism profile and in vivo properties. Several analo...
Acta Pol. Pharm. 70(6) , 951-9, (2013)
Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals wer...