3-Acetyl-2,5-dichlorothiophene

Names

[ Name ]:
3-Acetyl-2,5-dichlorothiophene

[Synonym ]:
1-(2,5-Dichlorothiophen-3-yl)ethanone
1-(2,5-Dichloro-3-thienyl)ethanone
EINECS 252-893-3
MFCD00014522
Ethanone, 1-(2,5-dichloro-3-thienyl)-
3-Acetyl-2,5-dichlorothiophene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
233.9±40.0 °C at 760 mmHg

[ Melting Point ]:
37-40 °C(lit.)

[ Molecular Formula ]:
C₆H₄Cl₂OS

[ Molecular Weight ]:
195.066

[ Flash Point ]:
95.3±27.3 °C

[ Exact Mass ]:
193.935989

[ PSA ]:
45.31000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
Refrigerator

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S22-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,5-Dichlorothiophene
Acetyl chloride

DownStream

5-Chlorothiophene-3-carboxylic acid
2,5-Dichlorothiophene-3-Carboxylic Acid
4,5-Dichloro-3-thiophenecarboxylic acid
3-Acetylthiophene
1-(5-Chloro-3-thienyl)ethanone
3-acetyl-2-chlorothiophene
Brinzolamide
(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
1-(2-(benzylthio)-5-chlorothiophen-3-yl)ethanone
(S)-6-Chloro-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety.

Bioorg. Med. Chem. Lett. 17 , 5321-4, (2007)

Two new series of chalcones have been synthesized by reacting 1-(4-piperazin-1-yl-phenyl)ethanone and 1-(2,5-dichloro-3-thienyl)-1-ethanone with different substituted benzaldehydes in turn by Claisen-...

Enantioselective Synthesis of Brinzolamide (AL-4862), a New Topical Carbonic Anhydrase Inhibitor. The “DCAT Route” to Thiophenesulfonamides. Conrow RE, et al.

Org. Process Res. Dev. 3(2) , 114-20, (1999)

Facile synthesis of 2-(substituted amino)-4H-thieno [3, 2-e]-1, 3-thiazin-4-ones. Abu-El-Halawa R, et al.

Monatsh. Chem 139(10) , 1251-55, (2008)

3-acetyl-2,5,7-trimethyl-chromen-4-one
3-Acetyl-2,5,6,7-tetrahydroxy-1,4-naphthoquinone
3-Acetyl-2,5-dibromothiophene
3-ACETYL-2,5-DIMETHYLFURAN
3-acetyl-2,5-dimethoxycyclohexa-2,5-diene-1,4-dione
3-acetyl-2,5-dihydrothiophene
Tert-butyl 6-amino-1,3-dioxaindane-4-carboxylate
1,4-dimethyl-5-[(2S)-oxiran-2-yl]-1H-pyrazole
tert-butyl 2-[5-amino-3-(pentan-2-yl)-1H-pyrazol-1-yl]acetate
3-[(6-Bromo-2-ethylquinazolin-4-yl)sulfanyl]propanoic acid
1-(1,4-dimethyl-1H-pyrazol-5-yl)-3-hydroxycyclobutane-1-carboxylic acid
2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-[1,3]thiazolo[4,5-b]pyridine-6-carboxylic acid
5-{[(Tert-butoxy)carbonyl]amino}-3-(oxan-4-yl)-1,2-thiazole-4-carboxylic acid
2-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}-6-(trifluoromethyl)pyridine-3-carboxylic acid
3-(4,5-dimethyl-1H-imidazol-1-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanoic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyridin-3-yl]acetic acid

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