2,5-Difluoronitrobenzene

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Names

[ CAS No. ]:
364-74-9

[ Name ]:
2,5-Difluoronitrobenzene

[Synonym ]:
2,5-Difluoro-1-nitrobenzene
1,4-Difluoro-2-nitrobenzene
2,5-Difluoronitroben
Benzene, 1,4-difluoro-2-nitro-
3,5-diflurobenzalcohol
EINECS 206-663-4
2,5-difluoronitro-benzene
1,4-difluoro-2-nitro-benzen
1-Nitro-2,5-difluorobenzene
2,5-Difluoronitrobenzene
2,4-DIFLUOROCINNAMIC ACD
MFCD00007054
1-fluoro-2-nitro-4-fluorobenzene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
206.5±0.0 °C at 760 mmHg

[ Melting Point ]:
−11.7 °C(lit.)

[ Molecular Formula ]:
C6H3F2NO2

[ Molecular Weight ]:
159.090

[ Flash Point ]:
90.0±0.0 °C

[ Exact Mass ]:
159.013184

[ PSA ]:
45.82000

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.510

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ5715000
CHEMICAL NAME :
Benzene, 1,4-difluoro-2-nitro-
CAS REGISTRY NUMBER :
364-74-9
BEILSTEIN REFERENCE NO. :
2210200
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H3-F2-N-O2
MOLECULAR WEIGHT :
159.10
WISWESSER LINE NOTATION :
WNR BF EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
160 nL/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,217,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
CZ5715000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2904909090

Precursor & DownStream

Precursor

  • 1,4-Difluorobenzene
  • 2,4-Dinitrochlorobenzene
  • 2,5-Difluoroaniline

DownStream

  • 4-Fluoro-2-nitrophenol
  • 2,5-Difluoroaniline
  • 2,2',5,5'-tetrafluoroazoxybenzene
  • 4-fluoro-1-[(2-methylpropan-2-yl)oxy]-2-nitrobenzene
  • N-ISOPROPYL-4-FLUORO-2-NITROANILINE
  • N-(2,5-difluorophenyl)benzamide
  • Methyl (4-fluoro-2-nitrophenyl)acetate
  • N-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-4-fluoro-2-nitroaniline
  • 2',5'-Difluoroacetanilide
  • 1-(4-Fluoro-2-nitrophenyl)piperidine

Customs

[ HS Code ]: 2904909090

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

A combined experimental and computational thermodynamic study of difluoronitrobenzene isomers.

J. Phys. Chem. B 114(40) , 12914-25, (2010)

This work reports the experimental and computational thermochemical study performed on three difluorinated nitrobenzene isomers: 2,4-difluoronitrobenzene (2,4-DFNB), 2,5-difluoronitrobenzene (2,5-DFNB...

Different metabolic pathways of 2,5-difluoronitrobenzene and 2,5-difluoroaminobenzene compared to molecular orbital substrate characteristics.

Chem. Biol. Interact. 94(1) , 49-72, (1995)

The in vivo metabolite patterns of 2,5-difluoroaminobenzene and of its nitrobenzene analogue, 2,5-difluoronitrobenzene, were determined using 19F NMR analysis of urine samples. Results obtained demons...

In vitro metabolism of 5-fluoro-2-glutathionyl-nitrobenzene by kidney proximal tubular cells studied by 19F-NMR.

Chem. Biol. Interact. 98(2) , 97-112, (1995)

Proximal tubular biotransformation of the glutathionyl (GSH) conjugate derived from 2,5-difluoronitrobenzene (5-fluoro-2-glutathionyl-nitrobenzene) was studied by means of 19F-NMR. This method allows ...


More Articles

Related Compounds

  • 3-Bromo-2,5-difluoronitrobenzene
  • 4-Bromo-2,5-Difluoronitrobenzene
  • 2-(5-chlorothiophen-2-yl)acetonitrile
  • 2-(5-amino-6-chloropyrimidin-4-yl)sulfanylacetonitrile
  • 2-(5-trimethylsilylpent-4-ynyl)cyclohepta-2,4,6-trien-1-one
  • 2-[5-Bromo-2-(hydroxymethyl)phenyl]ethanol
  • 2-{[(5-Chlorofuran-2-yl)methyl]sulfanyl}-2-methylpropan-1-amine
  • (4-{[(5-Chlorofuran-2-yl)methyl]sulfanyl}butan-2-yl)(ethyl)amine
  • tert-butyl (2E)-3-[4-(cyanomethoxy)phenyl]prop-2-enoate
  • tert-butyl (2E)-3-[3-chloro-5-methoxy-4-(propan-2-yloxy)phenyl]prop-2-enoate
  • tert-butyl (2E)-3-(5-methoxy-2-methyl-2,3-dihydro-1-benzofuran-6-yl)prop-2-enoate
  • N-(4-amino-2,3-dihydro-1H-inden-1-yl)butane-1-sulfonamide
  • N-(4-amino-2,3-dihydro-1H-inden-1-yl)cyclopropanesulfonamide
  • N-(1-amino-2,3-dihydro-1H-inden-4-yl)cyclopropanesulfonamide
  • (8aR)-2-methyl-octahydropyrrolo[1,2-a]piperazine-1,4,7-trione
  • 4-(3-Amino-4-methoxypyrrolidin-1-yl)pyrimidin-2-amine
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