4-Fluoro-3-nitroaniline
Suppliers
Names
[ CAS No. ]:
364-76-1
[ Name ]:
4-Fluoro-3-nitroaniline
[Synonym ]:
4-Fluoro-3-nitro-phenylamine
4-Fluoro-3-nitrobenzenamine
3-nitro-4-fluoroaniline
4-Fluoro-3-nitroaniline
EINECS 206-665-5
3-nitro-4-fluoroanailine
4-amino-1-fluoro-2-nitrobenzene
4-fluoro-5-nitroaniline
Benzenamine,4-fluoro-3-nitro
5-amino-2-fluoronitrobenzene
MFCD00007833
Benzenamine, 4-fluoro-3-nitro-
4'-fluoro-3'-nitroaniline
ZR DF CNW
Aniline,4-fluoro-3-nitro
4-Amino-2-nitrofluorobenzene
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
331.3±22.0 °C at 760 mmHg
[ Melting Point ]:
94-96 °C(lit.)
[ Molecular Formula ]:
C6H5FN2O2
[ Molecular Weight ]:
156.115
[ Flash Point ]:
91.1±0.0 °C
[ Exact Mass ]:
156.033508
[ PSA ]:
71.84000
[ LogP ]:
1.27
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.603
[ Water Solubility ]:
Insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BY1700000
- CHEMICAL NAME :
- Aniline, 4-fluoro-3-nitro-
- CAS REGISTRY NUMBER :
- 364-76-1
- BEILSTEIN REFERENCE NO. :
- 2210199
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C6-H5-F-N2-O2
- MOLECULAR WEIGHT :
- 156.13
- WISWESSER LINE NOTATION :
- ZR DF CNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >200 gm/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1080 mg/kg/90D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - change in clotting factors Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,400,1984
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S36/37-S37/39-S26
[ RIDADR ]:
UN 1325 4.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
BY1700000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
29214210
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921420090
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
J. Neurochem. 45(3) , 940-5, (1985)
We had previously shown that 4-fluoro-3-nitrophenyl azide (FNPA) is a competitive inhibitor of both types of monoamine oxidase (MAO) in the dark, but it is a preferential photoaffinity label for only ...
Toxicol. Appl. Pharmacol. 72(3) , 400-5, (1984)
4-Fluoro-3-nitroaniline (4-F-3-NA), an intermediate used in the production of commercial hair dyes, was administered daily for 90 days via po intubation to Charles River CD rats at doses of 40, 120, o...