Ikarugamycin
Suppliers
Names
[ CAS No. ]:
36531-78-9
[ Name ]:
Ikarugamycin
[Synonym ]:
14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
(3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-Ethyl-28-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.0.0.0]octacosa-1(28),3,13,18-tetraene-2,20,27-trione
Ikarugamycin
tu-6239 c3
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
741.9±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C29H38N2O4
[ Molecular Weight ]:
478.62
[ Flash Point ]:
402.5±32.9 °C
[ Exact Mass ]:
478.283173
[ PSA ]:
95.50000
[ LogP ]:
5.05
[ Vapour Pressure ]:
0.0±5.6 mmHg at 25°C
[ Index of Refraction ]:
1.604
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI0625500
- CHEMICAL NAME :
- Ikarugamycin
- CAS REGISTRY NUMBER :
- 36531-78-9
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C29-H38-N2-O4
- MOLECULAR WEIGHT :
- 478.69
- WISWESSER LINE NOTATION :
- T I5 H6 F5-17-5 A CV UVM D&MV DU NU SU C&HTTTT&J AQ L2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Hazard Codes ]:
T
[ RIDADR ]:
UN 2811 6.1 / PGIII
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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