Aliskiren inter-10

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Names

[ CAS No. ]:
365541-74-8

[ Name ]:
Aliskiren inter-10

[Synonym ]:
(R)-4-benzyl-3-((S)-2-(benzyloxymethyl)-3-methylbutanoyl)oxazolidin-2-one
(4R)-3-{(2S)-3-methyl-1-oxo-2-[(phenylmethoxy)methyl]butyl}-4-(phenylmethyl)oxazolidin-2-one
(4R)-3-[(2S)-3-Methyl-1-oxo-2-[(phenylmethoxy)methyl]butyl]-4-(phenylmethyl)-2-oxazolidinone
(3(2S),4R)-4-benzyl-3-(2-[(benzyloxy)methyl]-3-methyl-1-oxobutyl)-2-oxazolidinone

Chemical & Physical Properties

[ Density]:
1.165

[ Boiling Point ]:
535.9ºC at 760 mmHg

[ Melting Point ]:
74-75ºC

[ Molecular Formula ]:
C23H27NO4

[ Molecular Weight ]:
381.46500

[ Exact Mass ]:
381.19400

[ PSA ]:
55.84000

[ LogP ]:
4.00340

[ Index of Refraction ]:
1.566

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzyl chloromethyl ether
  • (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
  • Benzyl 2,2,2-trichloroacetimidate
  • 4-benzyloxazolidin-2-one
  • 3-Methylbutanoyl chloride
  • Benzyl alcohol

DownStream

  • Aliskiren
  • 1-(((S)-2-(Bromomethyl)-3-methylbutoxy)methyl)benzene
  • tert-butyl N-[(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-2,9-dimethyldecan-5-yl]carbamate
  • tert-Butyl ((1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate

Related Compounds

  • Aliskiren inter-9
  • Aliskiren inter-7
  • Methyl (2S,4E)-5-chloro-2-isopropylpent-4-enoate
  • (2S,4E)-5-Chloro-N,N-dimethyl-2-(1-methylethyl)-4-pentenamide
  • (2S,4E)-5-Chloro-2-isopropyl-4-pentenoic acid
  • Aliskiren fumarate
  • 2-{[(Benzyloxy)carbonyl]amino}-[1,3]thiazolo[4,5-b]pyridine-6-carboxylic acid
  • 5-(2-methylbutan-2-yl)-3-(piperidin-3-yl)-4,5,6,7-tetrahydro-1H-indazole
  • 3-(azetidin-3-yl)-5-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1H-indazole
  • 5-(2-methylbutan-2-yl)-3-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-indazole
  • tert-butyl 3-[5-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1H-indazol-3-yl]azetidine-1-carboxylate
  • 2-[5-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1H-indazol-3-yl]aniline
  • tert-butyl 4-(5-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)piperidine-1-carboxylate
  • 5-methyl-3-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-indazole
  • 2-(5-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)aniline
  • Methyl 2-[1-(3-{[(tert-butoxy)carbonyl]amino}phenyl)cyclopropyl]-2-hydroxyacetate
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