Aliskiren inter-10

Suppliers

Names

[ Name ]:
Aliskiren inter-10

[Synonym ]:
(R)-4-benzyl-3-((S)-2-(benzyloxymethyl)-3-methylbutanoyl)oxazolidin-2-one
(4R)-3-{(2S)-3-methyl-1-oxo-2-[(phenylmethoxy)methyl]butyl}-4-(phenylmethyl)oxazolidin-2-one
(4R)-3-[(2S)-3-Methyl-1-oxo-2-[(phenylmethoxy)methyl]butyl]-4-(phenylmethyl)-2-oxazolidinone
(3(2S),4R)-4-benzyl-3-(2-[(benzyloxy)methyl]-3-methyl-1-oxobutyl)-2-oxazolidinone

Chemical & Physical Properties

[ Density]:
1.165

[ Boiling Point ]:
535.9ºC at 760 mmHg

[ Melting Point ]:
74-75ºC

[ Molecular Formula ]:
C₂₃H₂₇NO₄

[ Molecular Weight ]:
381.46500

[ Exact Mass ]:
381.19400

[ PSA ]:
55.84000

[ LogP ]:
4.00340

[ Index of Refraction ]:
1.566

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Aliskiren
1-(((S)-2-(Bromomethyl)-3-methylbutoxy)methyl)benzene
tert-butyl N-[(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-2,9-dimethyldecan-5-yl]carbamate
tert-Butyl ((1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate