1,2-Difluorobenzene

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Names

[ CAS No. ]:
367-11-3

[ Name ]:
1,2-Difluorobenzene

[Synonym ]:
ortho-difluorobenzene
Isoamylamine
o-Difluorobenzene
2-Difluorobenzene
o-difluoro-benzen
1,2-Difluorobenzene
EINECS 206-680-7
Benzene,o-difluoro
1,2-difluroethylene
1,2-difluoro-benzene
FR BF
difluorobenzene
1,2-Difluorbenzol
MFCD00000284
1,2-diflurobenzene
Benzene, 1,2-difluoro-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
93.3±13.0 °C at 760 mmHg

[ Melting Point ]:
−34 °C(lit.)

[ Molecular Formula ]:
C₆H₄F₂

[ Molecular Weight ]:
114.093

[ Flash Point ]:
2.2±0.0 °C

[ Exact Mass ]:
114.028107

[ LogP ]:
2.23

[ Vapour Pressure ]:
56.6±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Highly flammable. Note low flash point.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5655000

CHEMICAL NAME :: Benzene, o-difluoro-

CAS REGISTRY NUMBER :: 367-11-3

BEILSTEIN REFERENCE NO. :: 1905113

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H4-F2

MOLECULAR WEIGHT :: 114.10

WISWESSER LINE NOTATION :: FR BF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 gm/m3/2H

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225

[ Precautionary Statements ]:
P210

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R20

[ Safety Phrases ]:
S7-S16-S29-S33

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
CZ5655000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29036990

Precursor & DownStream

Precursor

2-Fluoroaniline
N-ethyldiethanolamine
2,3-Difluorochlorobenzene
1-Chloro-2-fluorobenzene
1,2-Dinitrobenzene
1-Chloro-4-fluorobenzene
4-Chloro-1,2-difluorobenzene
4-chloro-4,5,5-trifluoro-1-cyclohexene
Fluorobenzene

DownStream

3,4-Difluorobenzoic acid
3-Fluorobenzoic acid
3,4-Difluoronitrobenzene
2-Fluoro-4-nitroanisole
1-(2-Fluoro-4-nitrophenyl)pyrrolidine
1,3-Difluorobenzene
1,4-Difluorobenzene
Fluorobenzene
benzene
1-(3,4-Difluorophenyl)ethanone

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Vibrational spectra and trace determination of p-difluorobenzene and ethylbenzene.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 107 , 1-7, (2013)

In this work, the structures and normal vibrations of p-difluorobenzene and ethylbenzene in the first excited state have been studied using resonant two-photon ionization spectrum and ab initio quantu...

Ionized o-, m-, and p-difluorobenzene dissociate through ring-opened intermediates: a TPEPICO investigation.

J. Am. Soc. Mass Spectrom. 20(1) , 20-4, (2009)

Threshold photoelectron photoion coincidence (TPEPICO) experiments have shown that o-, m-, and p-difluorobenzene ions dissociate via a common, ring-opened intermediate and not via ionized p-difluorobe...

Regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes predicted by calculated frontier orbital substrate characteristics.

Biochemistry 32(18) , 4801-12, (1993)

In the present study, a hypothesis is presented for the prediction of the regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes. The regioselectivity of the in vivo hydroxylat...