dechloroethylcyclophosphamide

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Names

[ CAS No. ]:
36761-83-8

[ Name ]:
dechloroethylcyclophosphamide

[Synonym ]:
dechloroethylcyclophosphamide
Asta-4968
N-(2-chloroethy)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N-(2-Chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
deschloroethylcyclophosphamide
2-[(2-Chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
3-Deschloroethylifosfamide
N-Dechloroethylcyclophosphamide
3-Dechloroethylifosfamide
Monochloroethylcyclophosphamide
Monochloroethyl

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
272.1ºC at 760mmHg

[ Molecular Formula ]:
C5H12ClN2O2P

[ Molecular Weight ]:
198.58800

[ Flash Point ]:
118.4ºC

[ Exact Mass ]:
198.03200

[ PSA ]:
60.17000

[ LogP ]:
1.65250

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP5788670
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-2-amine, N-(2-chloroethyl)tetrahydro-, 2-oxide
CAS REGISTRY NUMBER :
36761-83-8
LAST UPDATED :
199404
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H12-Cl-N2-O2-P
MOLECULAR WEIGHT :
198.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Bird - chicken Cells - not otherwise specified
DOSE/DURATION :
70 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,115,1992

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-2-aziridin-1-yl-3-((R)-1-phenyl-ethyl)-[1,3,2]oxazaphosphinane 2-oxide
  • (2-chloro-ethyl)-[(S)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ5-[1,3,2]oxazaphosphinan-2-yl]-amine
  • (2-chloro-ethyl)-[(R)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ5-[1,3,2]oxazaphosphinan-2-yl]-amine
  • 2'-Oxo Ifosfamide
  • 2-Chloroethanamine hydrochloride
  • 3-Aminopropan-1-ol
  • Cyclophosphamide

DownStream

  • Ifosfamide
  • 3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
  • aminopropyl dihydrogen phosphate
  • 2-Chloroethanamine
  • 2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-ol

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%