Centrophenoxine hydrochloride

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Names

[ Name ]:
Centrophenoxine hydrochloride

[Synonym ]:
Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride
EINECS 222-975-3
Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride
2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride
MFCD00012533
Clocete
Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester hydrochloride
Centrophenoxine hydrochloride
Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (9CI)
2-(dimethylamino)ethyl 2-(4-chlorophenoxy)acetate,hydrochloride
2-(Dimethylamino)ethyl 4-Chlorophenoxyacetate Hydrochloride
2-(Dimethylamino)ethyl (4-chlorophenoxy)acetate hydrochloride (1:1)
Meclofenoxate Hydrochloride
Acetic acid, 2-(4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1)
Meclofenoxate (hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
345.9ºC at 760mmHg

[ Melting Point ]:
133-135°C

[ Molecular Formula ]:
C₁₂H₁₇Cl₂NO₃

[ Molecular Weight ]:
294.174

[ Exact Mass ]:
293.058563

[ PSA ]:
38.77000

[ LogP ]:
2.62560

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0440000

CHEMICAL NAME :: Acetic acid, (p-chlorophenoxy)-, 2-dimethylaminoethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 3685-84-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H16-Cl-N-O3.Cl-H

MOLECULAR WEIGHT :: 294.20

WISWESSER LINE NOTATION :: GR DO1VO2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 865 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963- Volume(issue)/page/year: 16(2),59,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 153,1914,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,814,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,814,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #398M

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 153,1914,1959

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S36

[ RTECS ]:
AG0440000

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(Dimethylamino)ethanol
Acetyl chloride,2-(4-chlorophenoxy)
4-CPA

DownStream

4-CPA
2-(Dimethylamino)ethanol hydrochloride (1:1)
2-(Dimethylamino)ethanol

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

3-(3-Fluorophenyl)-6-{4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]piperazin-1-yl}pyridazine
N4-[1-(benzenesulfonyl)piperidin-4-yl]-N4-cyclopropyl-N6,N6-dimethylpyrimidine-4,6-diamine
4-(5-Fluoro-6-methylpyrimidin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperazine-1-carboxamide
N-(3,4-dimethylphenyl)-4-{[(3-methoxypyrazin-2-yl)(methyl)amino]methyl}piperidine-1-carboxamide
3'-Fluoro-3-methoxy-[1,1'-biphenyl]-4-amine
(1S,2S)-2-(Methoxymethyl)cyclopropan-1-amine;hydrochloride
(S)-N-(1-((4-(N-(tert-Butyl)sulfamoyl)phenyl)amino)-1-oxo-3-(pyridin-4-yl)propan-2-yl)-4-fluorobenzamide
ethyl 5-amino-3-chloro-1-methyl-1H-pyrazole-4-carboxylate
tert-butyl (2S,4S)-2-(aminooxymethyl)-4-methyl-pyrrolidine-1-carboxylate
rac-methyl (2R,4S)-4-cyclohexylpiperidine-2-carboxylate

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