4-[2-(butylamino)-1-hydroxyethyl]phenol

Names

[ CAS No. ]:
3703-79-5

[ Name ]:
4-[2-(butylamino)-1-hydroxyethyl]phenol

[Synonym ]:
Butedrine
N-Butylnorsynephrine
Butyl-nor-sympatol
Butylsympathol
Bamethan
N-Dutylnorsympathol
Bamethane

Chemical & Physical Properties

[ Density]:
1.079g/cm3

[ Boiling Point ]:
375.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₉NO₂

[ Molecular Weight ]:
209.28500

[ Flash Point ]:
141.2ºC

[ Exact Mass ]:
209.14200

[ PSA ]:
52.49000

[ LogP ]:
2.20620

[ Index of Refraction ]:
1.545

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN9200000

CHEMICAL NAME :: Benzyl alcohol, alpha-((butylamino)methyl)-p-hydroxy-

CAS REGISTRY NUMBER :: 3703-79-5

BEILSTEIN REFERENCE NO. :: 1107993

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H19-N-O2

MOLECULAR WEIGHT :: 209.32

WISWESSER LINE NOTATION :: QR DYQ1M4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,272,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,272,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,297,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,271,1970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-butylamino-1-(4-hydroxy-phenyl)-ethanone
3-hydroxy-N-[(5-methoxy-2-nitro-4-phenylmethoxy-phenyl)methylideneamino]naphthalene-2-carboxamide

DownStream

Related Compounds

4-[2-(Butylamino)-1-hydroxyethyl]phenol sulfate
4-[2-(butylamino)-1-hydroxyethyl]phenol,hydrochloride
4-[2-(butylamino)-1-hydroxyethyl]phenol,pyridine-3-carboxylic acid
4-[2-(butylamino)-1-hydroxyethyl]benzene-1,2-diol
4-[2-(ethylamino)-1-hydroxyethyl]phenol
4-Bromo-2-(1-hydroxyethyl)phenol
Ethyl 3-[(3-chloro-2-methylphenyl)amino]-3-oxopropanoate
N-[3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-yl]-3-methyl-1-benzofuran-2-carboxamide
6-[[(2,2-Diethoxyethyl)amino]methyl]-5,8-dimethyl-9H-carbazol-3-yl 2,2-dimethylpropanoate
2,3-Dideoxy-4,5-O-(1-methylethylidene)-3-(nitromethyl)-L-threo-pentonic Acid Ethyl Ester
2-(5-Methylfuran-2-yl)propan-2-ol
4-(4-Ethylphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol
2-((6-amino-1-(3-methoxyphenyl)-4-oxo-1,4-dihydropyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
4,5-Difluoro-2-phenylpyrimidine
1-(benzo[d][1,3]dioxol-5-yl)-3-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)urea
2-(4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-N-(3-chloro-4-methylphenyl)acetamide